Biocompatible Hydrogel Composition for Prolonged Mucosal Retention
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Solution Overview
Problem
Existing hydroxyl-bearing water soluble polymers used in biomedical applications require complex and harsh modifications to achieve desired properties, making them unsuitable for practical use.
Innovation Solution
A composition of two biocompatible polymers with specific intrinsic viscosities and modifications forms a hydrogel with low storage modulus, high yield strain, and self-healing properties, suitable for spreading on surfaces and stable in water.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydroxyl-bearing water soluble polymers are modified for use as hydrogels, then desired functionality toward animal cells or tissues is achieved, but the modification process becomes complicated and requires harsh conditions
Solution Approach 1:
The patent introduces a complementary DNA sequence as an intermediary element that facilitates the formation of functional hydrogel structures. This intermediary sequence enables the polymers to self-assemble into hydrogels with desired biological functionality without requiring complex modification processes, thereby resolving the contradiction between achieving reliability and reducing process complexity
Solution Approach 2:
The hydroxyl-bearing water soluble polymers are designed to self-assemble into functional hydrogel structures through their inherent properties. The complementary DNA sequences enable the polymers to automatically organize and form hydrogels with desired functionality toward animal cells or tissues, eliminating the need for harsh modification conditions and reducing overall process complexity
2Reliability
If hydroxyl-bearing water soluble polymers are modified for use as hydrogels, then desired properties are achieved, but the modification conditions become harsh and expensive
Solution Approach 1:
The complementary DNA sequence acts as a mediator that enables the formation of functional hydrogel structures through self-assembly. This approach achieves desired properties such as functionality toward animal cells or tissues without subjecting the polymers to harsh modification conditions, thereby resolving the contradiction between reliability and harmful factors
Solution Approach 2:
The polymers utilize their inherent hydroxyl-bearing properties and the complementary DNA sequences to self-assemble into functional hydrogels. This self-service mechanism achieves desired properties without requiring harsh or expensive modification conditions, eliminating the need for external intervention that would introduce harmful factors
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogel exhibits ease of application, stability, and self-healing capabilities, making it suitable for biomedical applications without the need for complex chemistry.
Implementation Method 1
said first polymer derivative is capable of reacting with said second polymer derivative to form said hydrogel
Implementation Method 2
The present disclosure provides compositions consisting of two polymers (e.g., biocompatible polymers) capable of forming a hydrogel
Data Source
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AI summary
The compositions comprise one or more polymers capable of forming a hydrogel and methods for making and using the hydrogel. More specifically, the compositions comprise one or more polymers capable of forming a hydrogel with prolonged mucosal retention, and methods for making and using the hydrogel.