Biocompatible Hydrogel Adhesives for Rapid Gelation and Strong Tissue Bonding

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Solution Overview

Problem

Existing tissue adhesives are unsuitable for many applications due to toxic degradation products, slow curing, poor mechanical strength, and insufficient adhesion.

Innovation Solution

A biocompatible adhesive material comprising a block copolymer with polyethylene oxide and polypropylene oxide blocks and primary amine groups, crosslinked with an oxidized polysaccharide through imine moieties, forming a hydrogel.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If conventional tissue adhesives are used, then adhesion function is provided, but toxic degradation products are generated

Engineering Contradiction:

Improvetoxic degradation productsVSAvoidadhesion function

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent changes the chemical composition parameters by using poloxamer (a non-toxic block copolymer) instead of conventional adhesive chemicals, and controls the degradation rate by adjusting molecular weight and crosslinking density. This resolves the contradiction by maintaining adhesion function while eliminating toxic degradation products through parameter optimization.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite hydrogel system combining poloxamer blocks with crosslinking agents to form a network structure. This composite material provides both the required adhesion strength and biocompatibility, resolving the contradiction between adhesion function and toxic degradation by integrating multiple material properties.

Inventive Principle:

Principle #40Composite materials

2Strength

If conventional hydrogel adhesives are used, then nontoxicity is achieved, but mechanical strength is insufficient

Engineering Contradiction:

Improvemechanical strengthVSAvoidnontoxicity

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The patent optimizes mechanical strength by controlling molecular weight, block ratio, and crosslinking density of the poloxamer hydrogel. By adjusting these parameters, the hydrogel achieves sufficient mechanical strength while maintaining nontoxicity, resolving the contradiction between strength and biocompatibility.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention forms a composite network structure by crosslinking poloxamer blocks with appropriate agents, creating a material that combines the nontoxic properties of poloxamer with enhanced mechanical strength through the crosslinked network architecture.

Inventive Principle:

Principle #40Composite materials

3Speed

If conventional hydrogel adhesives are used, then biocompatibility is improved, but adhesion speed is slow

Engineering Contradiction:

Improveadhesion speedVSAvoidbiocompatibility

Core Design Contradiction:

SpeedVSReliability

Solution Approach 1:

The patent accelerates adhesion speed by optimizing the concentration of reactive groups, molecular weight, and crosslinking density of the poloxamer hydrogel. These parameter changes enable rapid adhesion while preserving biocompatibility, resolving the contradiction between speed and reliability.

Inventive Principle:

Principle #35Parameter changes

4Loss of time

If conventional hydrogel adhesives are used, then nontoxicity is achieved, but gelation time is prolonged

Engineering Contradiction:

Improvegelation timeVSAvoidnontoxicity

Core Design Contradiction:

Loss of timeVSObject-affected harmful factors

Solution Approach 1:

The invention reduces gelation time by optimizing the concentration of crosslinking agents, molecular weight, and temperature conditions while using nontoxic poloxamer-based materials. This resolves the contradiction by achieving rapid gelation without compromising nontoxicity through careful parameter control.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The adhesive material provides rapid gelation, sufficient adhesion, and mechanical strength, suitable for sealing and treating biological and prosthetic materials, with potential for drug delivery and wound healing.

Implementation Method 1

the adhesive material is crosslinked by a plurality of imine moieties formed from the at least one primary amine of the block copolymer and the at least two aldehyde moieties of the oxidized polysaccharide

Methodology Applied

Scientific EffectImine formation: Chemical Bonding

Implementation Method 2

combining the first component and the second component, thereby producing an adhesive formulation; allowing the adhesive formulation to cure in contact with the surface of the one or more biological tissues

Methodology Applied

Scientific EffectGelation: Gel

Data Source

PatentUS20250281664A1Biocompatible adhesive materials and methods of use

Publication Date: 2025.09.11 BIODEVEK INC

AI summary

Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a functionalized poloxamer component and an oxidized polysaccharide component, and may be tailored for specific tissue types and conditions.