Biocompatible Microsphere Lesion Labeling Composition
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Solution Overview
Problem
Current methods for labeling cancerous lesions during surgery lack accuracy and persistence, leading to excessive tissue removal and challenges in identifying lesions post-chemotherapy, as existing dyes do not remain at the injection site for an extended period.
Innovation Solution
A biocompatible composition of microspheres containing a dye and biological protein, encapsulated in a biocompatible polymer, which is administered directly to the lesion site to provide long-term visibility and accurate lesion identification.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional dyes are used for lesion labeling, then the labeling can be applied easily, but the dye does not remain at the injection site for an extended period, leading to loss of labeling ability
Solution Approach 1:
The patent uses composite microspheres comprising a biocompatible polymer matrix combined with fluorescent dye molecules. This composite structure allows the dye to be trapped within the polymer network, preventing diffusion while maintaining fluorescence properties. The biocompatible polymer acts as a carrier that retains the dye at the injection site for extended periods (weeks to months) without compromising the fluorescent signaling capability, thus simultaneously improving duration and reliability of lesion labeling
Solution Approach 2:
The fluorescent dye molecules are nested within the biocompatible polymer matrix of the microspheres. This nesting structure physically confines the dye molecules within the polymer network, preventing their diffusion away from the injection site while allowing the outer polymer shell to provide structural stability and biocompatibility. The nested configuration enables the inner dye component to maintain its labeling function over extended periods
2Reliability
If a large margin is removed during surgery to ensure complete lesion removal, then the lesion can be completely removed, but excessive normal tissue is lost
Solution Approach 1:
The patent employs fluorescent dyes that emit light at specific wavelengths when excited, creating a visible color signal that highlights the lesion boundaries. This optical contrast allows surgeons to precisely identify the extent of the lesion and its margins in real-time during surgery, enabling complete removal of abnormal tissue while preserving surrounding normal tissue that does not exhibit the fluorescent signal
Solution Approach 2:
The fluorescent labeling provides real-time visual feedback to the surgeon during the surgical procedure. By observing the fluorescent signal distribution, the surgeon can continuously monitor the resection margins and adjust the surgical approach to ensure complete lesion removal while minimizing normal tissue loss. This feedback mechanism enables precise control over the surgical resection boundaries
3Loss of substance
If surgical scope is reduced without precise lesion knowledge, then less tissue is removed, but the tumor may remain in the resection margin
Solution Approach 1:
The fluorescent dye provides optical contrast that clearly delineates the lesion boundaries from surrounding normal tissue. This visual guidance allows surgeons to confidently reduce the surgical scope to only the necessary margins while ensuring complete tumor removal, as the fluorescent signal clearly indicates where tumor tissue ends and normal tissue begins, eliminating the need for excessive safety margins
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition allows for real-time identification of lesion size and location during surgery, reducing excessive tissue removal and maintaining visibility for several months, enhancing surgical precision and reducing normal tissue loss.
Implementation Method 1
encapsulated in a biocompatible polymer
Implementation Method 2
a dye for biological tissue... fluorescent dye... to provide long-term visibility and accurate lesion identification
Data Source
AI summary
The disclosure relates to a composition for labeling a target lesion, in form of microspheres including a biocompatible polymer; and a dye for biological tissue,and directly administered to a target lesion to confirm size and location of the target lesion in real time during surgery at a target site and a method preparing the same. The composition for labeling a target lesion of the present disclosure, when injected into a target lesion, remains there for several months and can detect the location and size of the labeled lesion in real time during surgery, thereby not only improving the success rate of surgical operation for the target lesion, but also preventing excessive loss of normal tissue, and therefore can be widely utilized as an effective surgical marker.