Biocompatible Nanoparticles via Electron Beam Crosslinking
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Solution Overview
Problem
Current methods for producing nanoparticles for drug delivery and medical applications often require the use of organic solvents and crosslinking agents, which can be toxic and complicate the manufacturing process, and do not achieve biocompatibility and biodegradability effectively.
Innovation Solution
Biocompatible nanoparticles are formed through inter-molecular or intra-molecular crosslinking of polysaccharides or polyethylene glycol using electron beam irradiation without the need for organic solvents or crosslinking agents, allowing for the conjugation of therapeutic agents and use as drug delivery systems or contrast agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If organic solvents and crosslinking agents are used to produce nanoparticles, then nanoparticle formation is achieved, but toxicity and complexity of manufacturing process increase
Solution Approach 1:
The patent removes organic solvents and crosslinking agents from the nanoparticle formation process. By extracting these harmful components, the method achieves biocompatible nanoparticles that can be degraded by body enzymes without causing toxicity, while still enabling effective nanoparticle formation for drug delivery applications
Solution Approach 2:
The patent employs self-assembly mechanisms where amphiphilic molecules automatically organize into nanoparticle structures in aqueous environments. This self-service approach eliminates the need for external crosslinking agents or organic solvents, allowing the system to form nanoparticles through intrinsic molecular properties and achieve biocompatibility
2Ease of manufacture
If organic solvents are used in nanoparticle production, then nanoparticle formation is enabled, but manufacturing process complexity and cost increase
Solution Approach 1:
The patent replaces complex mechanical and chemical processing steps with physical self-assembly mechanisms. Instead of using organic solvents requiring evaporation and crosslinking agents requiring chemical reactions, the method uses amphiphilic molecules that automatically assemble into nanoparticles through their inherent structural properties, significantly simplifying the manufacturing process
Solution Approach 2:
The patent changes the fundamental parameters of nanoparticle formation from chemical-driven (organic solvents, crosslinking reactions) to physical-driven (amphiphilic self-assembly in aqueous environments). This parameter change enables simpler manufacturing processes without compromising nanoparticle formation capability
3Reliability
If conventional nanoparticle methods are used, then drug delivery capability is achieved, but biodegradability and environmental compatibility are reduced
Solution Approach 1:
The patent designs nanoparticles from biodegradable amphiphilic molecules that can be safely discarded and metabolized by body enzymes. The nanoparticles are constructed to break down into harmless products after performing their drug delivery function, eliminating long-term environmental or biological persistence issues associated with conventional synthetic nanoparticle materials
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method produces nanoparticles that are non-toxic, biodegradable, and easily producible, offering improved biocompatibility and efficiency in drug delivery and imaging applications, with enhanced control over particle size and release rates.
Implementation Method 1
biocompatible nanoparticles formed through inter-molecular crosslinking or intra-molecular crosslinking introduced by electron beam irradiation of an aqueous solution
Implementation Method 2
inter-molecular crosslinking or intra-molecular crosslinking introduced by electron beam irradiation
Data Source
AI summary
The present invention relates to a biocompatible nanoparticle and a use thereof and, more specifically, to a biocompatible nanoparticle formed by irradiation an electron beam to an aqueous solution comprising at least one substance selected from the group consisting of a polysaccharide, a derivative thereof and a polyethylene glycol, thereby inducing inter-molecular cross-linking or intra-molecular cross-linking, and to a use of the biocompatible nanoparticle in a drug carrier, a contrast agent, a diagnostic agent or an intestinal adhesion prevention agent or for disease prevention and treatment.