Biocompatible Substrate Biosensor for Real-Time Postoperative Monitoring
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Solution Overview
Problem
Current technologies for detecting postoperative complications are costly, lack diagnostic efficacy and efficiency, are not specific or sensitive, and fail to provide real-time detection, often requiring invasive methods and lengthy bacterial culture processes, which can lead to delayed diagnosis and severe patient outcomes.
Innovation Solution
A device comprising a biocompatible substrate with an adhesive layer, biosensors, a wireless communications interface, and a microcontroller that adheres to internal tissue to detect analytes and transmit data wirelessly for real-time monitoring of postoperative complications, using ion-selective electrodes and microfluidic channels for analyte detection and analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional detection methods (blood tests, radiology, bacterial culture) are used, then diagnostic accuracy can be achieved, but the process is time-consuming and costly
Solution Approach 1:
The patent replaces traditional mechanical/invasive detection methods (blood draws, radiology scans, bacterial cultures) with an optical detection system that uses light to detect analytes in bodily fluids. The optical detection device can identify complications such as anastomotic leaks, infections, and hemorrhages through non-invasive optical measurements, eliminating the time delays associated with traditional methods while maintaining diagnostic accuracy.
2Reliability
If invasive methods are used for detection, then diagnostic efficacy is improved, but patient discomfort and risk increase
Solution Approach 1:
The patent substitutes invasive mechanical procedures with non-invasive optical detection. The optical detection device measures analytes in bodily fluids (such as peritoneal fluid or blood) through optical properties without requiring needle punctures, surgical incisions, or other invasive interventions. This maintains the ability to detect complications reliably while eliminating the risks and discomfort associated with invasive methods.
3Reliability
If frequent hospital visits are required for monitoring, then detection reliability is maintained, but patient convenience and productivity decrease
Solution Approach 1:
The patent implements a portable optical detection device that can be used by patients at home or in outpatient settings, eliminating the need for frequent hospital visits. The device allows patients to perform their own monitoring of postoperative complications, with results that can be stored or transmitted to healthcare providers. This self-service capability maintains detection reliability through regular monitoring while significantly improving patient convenience and reducing disruption to daily life.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables cost-effective, accurate, and real-time detection of postoperative complications, reducing the risk of delayed diagnosis and improving patient outcomes by providing immediate data on health parameters.
Implementation Method 1
an adhesive layer at a surface of the substrate. The adhesive layer is configured to adhere the substrate to a carrier
Implementation Method 2
at least one biosensor disposed at the substrate. The at least one biosensor is configured to detect or measure at least one analyte in a body of the patient
Implementation Method 3
The microcontroller is connected to the at least one biosensor and the wireless communications interface. The microcontroller is configured to measure at least one signal from the at least one biosensor
Implementation Method 4
The microcontroller is configured to transmit data from the analysis through the wireless communications interface to a remote device
Data Source
AI summary
Detecting postoperative complications in a patient uses a substrate made of biocompatible or biodegradable material. An adhesive layer adheres the substrate to patient tissue, surgical tool, or medical device. A biosensor at the substrate detects or measures an analyte in the patient's body. The biosensor may be on the surface of the substrate or within a microchannel in the substrate. A separation or isolation structure may be provided to separate or isolate the analyte from other analytes prior to the biosensor. A microcontroller is disposed on the substrate and connected to the biosensor and to a wireless communications interface also disposed on the substrate. The microcontroller measures a signal from the biosensor and may perform an analysis on the measured signal. Measured data or data resulting from the analysis is transmitted through the wireless communications interface to a transdermal patch or other remote device for storage and display.