Biocomposite Dental Implant Material for Bone Integration
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Solution Overview
Problem
Dental implants often face issues with peri-implantitis, aseptic loosening, and long-term stability due to inadequate bone integration and soft tissue healing, despite bioactive coatings, which leads to delayed osteointegration and increased risk of infection.
Innovation Solution
A biocomposite comprising granules of beta-tricalcium phosphate coated with a biodegradable polymer and underglycosylated recombinant human bone sialoprotein (BSP), which forms a moldable and rapidly hardening mixture that enhances osteoinduction and osteoconduction, promoting bone regeneration and soft tissue healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional grafts and bioactive coatings are used, then bone integration is improved, but healing time is extended and long-term stability is compromised due to peri-implantitis and aseptic loosening
Solution Approach 1:
The patent changes the chemical and physical parameters of the graft material by using beta-tricalcium phosphate in the beta-crystal form with specific particle size distributions (30-200 μm) and coating it with biodegradable polymers at controlled ratios (70-90% TCP, 10-30% polymer). This optimization of material parameters accelerates bone integration while maintaining long-term stability.
Solution Approach 2:
The invention creates a composite material combining beta-tricalcium phosphate granules with biodegradable polymers (PLA, PGA, or PLGA copolymers). This composite structure provides both immediate osteoconduction from the TCP and controlled degradation properties from the polymer, achieving rapid healing without compromising long-term implant stability.
2Ease of operation
If moldable graft materials are used for easy placement, then ease of operation is improved, but mechanical strength and structural stability deteriorate
Solution Approach 1:
The patent achieves moldability by controlling the particle size distribution of beta-TCP granules (30-200 μm) and the polymer content (10-30%), allowing the mixture to be molded during placement. The mechanical strength is maintained through the high TCP content (70-90%) and the specific biodegradable polymer selection, creating a material that is both moldable and mechanically robust.
3Productivity
If rapid bone healing is achieved through aggressive osteoinduction, then productivity is improved, but fibrous union and soft tissue overgrowth increase
Solution Approach 1:
The patent applies local quality control by using beta-tricalcium phosphate with specific particle size ranges (30-200 μm) that provide optimal surface area for osteoblast attachment while preventing excessive fibrous tissue formation. The biodegradable polymer coating is applied at controlled concentrations to stimulate bone healing without inducing soft tissue overgrowth, achieving rapid osteogenesis with minimal harmful effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biocomposite accelerates bone integration, reduces healing time, and inhibits fibrous union, providing a stable mechanical barrier for dental implants while promoting angiogenesis and osteogenesis, thus improving the long-term stability and reducing the risk of implant-related infections.
Implementation Method 1
enhances osteoinduction and osteoconduction, promoting bone regeneration
Implementation Method 2
enhances osteoinduction and osteoconduction, promoting bone regeneration
Implementation Method 3
forms a moldable and rapidly hardening mixture
Implementation Method 4
promoting angiogenesis and osteogenesis
Implementation Method 5
promoting angiogenesis and osteogenesis
Data Source
Figure 1A~1E
Figure 2A~2C
Figure 3A~3C
AI summary
A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically effective amount of underglycosylated recombinant human BSP as a mutidental clathrate with a basic organic compound which simulataneously is active as a plasticizer for the biodegradable polymer. The biocomposite is moldable and shapable, hardens rapidly in situ when placed by surgery or prosthetic dentistry and which furthers osseous repair and the healing of damage or diseased tissues and lesions.