Biocomposite Material for Endodontic Regeneration
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Solution Overview
Problem
Current materials fail to effectively promote dentin and pulp regeneration in pulp capping, biopulpotomy, and tooth perforation, leading to poor prognosis and high risk of pulp necrosis, and there is a need for biocompatible materials that can facilitate healing and prevent pulp necrosis.
Innovation Solution
A biocomposite material comprising a biopolymer matrix component, such as thiol-triacrylate, and bioactive filler components like bioglass, vitamin D, and atorvastatin, which is hardened using UV radiation, suitable for use in biopulpectomy, pulp capping, and tooth perforation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current materials are used for pulp capping and biopulpotomy, then the procedure can be performed, but the prognosis is poor with high risk of pulp necrosis and failure
Solution Approach 1:
The patent employs a composite material comprising a biopolymer matrix (such as gelatin, collagen, or chitosan) combined with bioactive glass particles and growth factors (BDGF). This composite structure integrates the biocompatibility and structural support of the biopolymer matrix with the regenerative properties of bioactive glass and the proliferative effects of BDGF, thereby improving pulp regeneration outcomes and reducing necrosis risk compared to conventional single-material approaches
Solution Approach 2:
The patent modifies the chemical and physical parameters of the capping material by incorporating specific ratios of bioactive glass particles (45-55 μm diameter) and controlling the release kinetics of bound growth factors. The material's porosity, surface area, and degradation rate are optimized to match pulp regeneration requirements, transforming the material properties to achieve better clinical prognosis
2Reliability
If pulp capping is performed to preserve vital pulp, then the pulp can be saved without necrosis in ideal cases, but the technique has poor prognosis and high failure rate
Solution Approach 1:
The biocomposite material is designed to self-regenerate pulp tissue through the sustained release of bound growth factors (BDGF) from the bioactive glass particles. The material autonomously provides regenerative signals to stimulate dentin bridge formation and pulp tissue regeneration without requiring additional external interventions, thereby improving healing efficiency and reliability
Solution Approach 2:
The growth factors are pre-bound to the bioactive glass particles during material fabrication, creating a reservoir of regenerative signals that are released in a controlled manner over time. This preliminary preparation ensures that regenerative factors are available exactly when needed during the pulp healing process, enhancing the overall effectiveness of pulp preservation
3Ease of manufacture
If biopulpotomy is performed with fixating agents on remaining pulp, then the procedure is simple, but there is no hope for pulp or dentine regeneration
Solution Approach 1:
The patent replaces conventional fixating agents with a biocomposite material that maintains procedural simplicity while fundamentally changing the outcome from mere fixation to active regeneration. The composite of biopolymer matrix, bioactive glass, and growth factors provides both the ease of application similar to traditional materials and the additional benefit of stimulating pulp and dentin regeneration
4Reliability
If conventional filling materials are used for tooth perforation, then obturation can be attempted, but success is not guaranteed due to difficulties in material handling and manipulation
Solution Approach 1:
The biocomposite material's rheological parameters are optimized to provide optimal working time and viscosity for easy manipulation during perforation repair. The material can be easily adapted to the perforation site and controlled in its placement, while maintaining stability once set, thereby improving both ease of operation and obturation success
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biocomposite material effectively promotes dentin and pulp regeneration, reducing the risk of pulp necrosis and improving the prognosis of dental procedures by providing a biocompatible and efficient healing solution.
Implementation Method 1
A biocomposite material comprising a biopolymer matrix component, such as thiol-triacrylate, and bioactive filler components like bioglass, vitamin D, and atorvastatin, which is hardened using UV radiation
Data Source
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Figure 3
AI summary
The present invention relates to a biocomposite material comprising at least one biopolymer matrix component and at least one bioactive filler component, to a method of manufacturing thereof, a method of hardening thereof, as well as to the use of said biocomposite material in biopulpectomy procedures for temporary or permanent teeth, in direct or indirect pulp capping, as a retrograde filling material for endodontic surgery, or for tooth or root perforation.