Biodata Test Strip With Hydrophilic Layer For Uniform Blood Spread
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Solution Overview
Problem
Conventional test strips for measuring LDL cholesterol levels suffer from measurement errors due to uneven blood spreadability across different regions, leading to unreliable reproducibility of biomedical data.
Innovation Solution
A test strip design featuring three application holes, a sectioned blood-filtering layer for erythrocytes and LDL cholesterol, and a hydrophilic layer to uniformly spread the blood sample, preventing erythrocyte infiltration into the reaction layer and enhancing blood spreadability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a conventional stacked structure with blood-filtering layer and color-developing membrane is used, then the test strip can measure biomedical data, but there is large deviation in smoothness of contact surface between layers causing uneven blood spreadability and measurement errors
Solution Approach 1:
A hydrophilic layer is introduced as an intermediary between the blood-filtering layer and the color-developing membrane. This hydrophilic layer acts as a mediator that uniformly spreads blood across the contact surface, eliminating the uneven spreadability caused by the conventional stacked structure while maintaining the filtering and color development functions.
Solution Approach 2:
The hydrophilic layer is designed with porous structure that allows uniform distribution of blood sample across the contact surface. The porous material enables controlled fluid flow and even spreading of blood without allowing erythrocytes to pass through to the color-developing membrane, thereby improving measurement reliability.
2Measurement precision
If the blood-filtering layer is designed to filter erythrocytes and LDL cholesterol, then the reaction layer can accurately measure biomedical data, but erythrocytes may infiltrate into the reaction layer causing measurement errors
Solution Approach 1:
The hydrophilic layer serves as an intermediary barrier between the blood-filtering layer and the reaction layer. It allows filtered blood components to pass through uniformly while blocking erythrocytes from infiltrating into the reaction layer, thus preventing measurement errors caused by erythrocyte interference.
Solution Approach 2:
The hydrophilic layer is positioned specifically at the interface where blood flow from the filtering layer meets the reaction layer. This localized placement creates a controlled zone that ensures uniform blood distribution and prevents erythrocyte infiltration exactly where it would cause measurement errors, without affecting other parts of the test strip structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution improves reproducibility by reducing measurement errors and ensuring consistent results, as demonstrated by lower coefficient of variation in reflectance graphs compared to conventional test strips.
Implementation Method 1
a hydrophilic layer of a hydrophilized porous mesh for uniformly spreading the blood sample filtered through the filtering layer
Implementation Method 2
a blood-filtering layer sectioned into: an erythrocyte and low-density lipoprotein (LDL) cholesterol-filtering zone located beneath the middle application hole of the three application holes and designed to filter off both of erythrocytes and low-density lipoprotein (LDL) cholesterol from an applied blood sample
Data Source
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AI summary
Disclosed is a test strip for measuring biomedical data, in which a hydrophilic material is introduced to improve the spreadability of blood. Having the structure comprising a blood-filtering layer designed to filter off either or both of erythrocytes and low-density lipoprotein (LDL) cholesterol from an applied blood sample; a reaction layer in which the blood sample free of erythrocytes and/or low-density lipoprotein (LDL) cholesterol is reacted with an reagent, and a hydrophilic layer, intercalated between the blood-filtering layer and the reaction layer, for uniformly spreading the blood sample filtered through the filtering layer, the blood-filtering layer and the reaction layer being stacked between the lower support and the upper cover, the test strip prevents the infiltration of erythrocytes into the reaction layer and improves the spreadability of blood to reduce measurement errors, thus bringing about higher reproducibility.