Biodegradable Delivery Particles with Cross-Linked Polymer Wall
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current microencapsulation technologies face challenges in retaining biodegradability and structural integrity for delivery particles in harsh environments, particularly in maintaining the encapsulation of small molecules and ensuring controlled release, while also being safe for human health and the environment.
Innovation Solution
The development of delivery particles with a core containing a benefit agent and a polymer wall formed by cross-linking water-soluble materials, such as poly(vinyl alcohol) and chitosan, using (meth)acrylate monomers and initiators to create a compact and stable structure that enhances biodegradability and resistance to leakage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If biodegradable materials are used to form delivery particles, then environmental safety and biodegradability are improved, but structural integrity and resistance to leakage deteriorate
Solution Approach 1:
The patent uses composite materials by combining biodegradable polymer matrices (such as poly(lactic acid), poly(glycidyl methacrylate-co-glycidyl trimethacrylate)) with cross-linking agents and functional additives to create delivery particles that maintain both biodegradability and structural integrity. The composite structure allows the particles to resist leakage while remaining environmentally safe and biodegradable.
2Duration of action of moving object
If mechanical rupture is used as the release mechanism, then controlled release at specific times is achieved, but the capsules are vulnerable to mechanical stress before the desired release time
Solution Approach 1:
The patent applies parameter changes by modifying the mechanical and chemical properties of the capsule shell through cross-linking and selection of specific polymers. This creates a shell that resists mechanical stress and maintains stability during storage and handling, while still enabling controlled release through mechanical rupture at the desired time. The cross-linked structure changes the mechanical parameters to provide both stability and controlled vulnerability.
3Reliability
If polymeric capsules are developed with low shell permeability and high deposition, then retention and protection capability are improved, but biodegradability deteriorates
Solution Approach 1:
The patent uses parameter changes by selecting specific biodegradable polymers and controlling their molecular weight, crystallinity, and cross-linking density to achieve low permeability and high deposition while maintaining biodegradability. The parameter optimization allows the shell to provide strong retention and protection capabilities without sacrificing environmental compatibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides biodegradable delivery particles with improved structural integrity and controlled release capabilities, ensuring the stability and safety of encapsulated benefit agents throughout their lifecycle, from inception to usage, while minimizing environmental impact.
Implementation Method 1
the polymer wall is formed by cross-linking of i. at least one water soluble material that has following Formula I... ii. at least one multi-functional monomer and/or oligomer comprising a radical polymerizable group
Implementation Method 2
at least one multi-functional monomer and/or oligomer comprising a radical polymerizable group
Implementation Method 3
Biodegradable materials exist and are able to form delivery particles via coacervation, spray-drying or phase inversion precipitation
Implementation Method 4
water soluble material that has following Formula I... in aqueous environment
Data Source
AI summary
A consumer product comprising a biodegradable delivery particle having a benefit agent containing core and a shell.