Biodegradable Ocular Patch with Refractory Center

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Solution Overview

Problem

Current treatments for ocular surface disorders, such as amniotic membrane transplantation, are costly, invasive, and may cause discomfort due to the need for external mechanical support, while amniotic membrane extracts lack physical characteristics necessary for a patch, leading to sub-optimal therapeutic outcomes.

Innovation Solution

A biodegradable, lens-shaped patch incorporating amniotic or placental extracts, designed to be applied non-surgically without external support, with a controlled degradation rate to provide sustained therapeutic benefits, acting as a bandage to promote healing and reduce inflammation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If amniotic membrane transplantation is performed surgically, then therapeutic benefits are achieved, but cost and surgical trauma increase

Engineering Contradiction:

Improvetherapeutic benefitVSAvoidsurgical trauma

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the mechanical surgical intervention system with a chemical/biological delivery system. Instead of surgically implanting amniotic membrane, the invention uses amniotic membrane extract incorporated into a contact lens that delivers therapeutic agents topically, eliminating surgical trauma while maintaining therapeutic benefits

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The contact lens acts as an intermediary carrier that delivers amniotic membrane extract to the ocular surface. This intermediary system provides the therapeutic benefits of amniotic membrane without requiring direct surgical transplantation, thereby reducing surgical trauma and cost

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If amniotic membrane is retained by a ring system, then healing is promoted, but patient comfort deteriorates

Engineering Contradiction:

Improvehealing promotionVSAvoidpatient comfort

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent extracts the amniotic membrane from the ring system and incorporates it directly into the contact lens material. This eliminates the need for the obtrusive ring system while maintaining the healing-promoting properties of amniotic membrane, thereby improving patient comfort

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention merges the therapeutic properties of amniotic membrane with the comfortable, well-tolerated contact lens platform. By combining these elements into a single integrated device, the patent achieves healing promotion without the discomfort associated with ring systems

Inventive Principle:

Principle #5Merging (Combining)

3Reliability

If amniotic membrane extract is applied topically, then inflammation is reduced, but physical patch characteristics are lost

Engineering Contradiction:

Improveinflammation reductionVSAvoidpatch physical characteristics

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent creates a composite material by incorporating amniotic membrane extract into the contact lens matrix. This composite structure provides both the anti-inflammatory properties of the extract and the physical characteristics of a patch, resolving the contradiction between therapeutic efficacy and physical stability

Inventive Principle:

Principle #40Composite materials

4Reliability

If amniotic membrane patch dissolves quickly, then multiple sessions are required, but sustained therapy is reduced

Engineering Contradiction:

Improvehealing effectVSAvoidpatch duration

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The contact lens provides continuous delivery of amniotic membrane extract to the ocular surface over an extended period. This continuous action maintains sustained therapeutic levels without requiring multiple application sessions, thereby extending the duration of effective treatment

Inventive Principle:

Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The patch effectively reduces inflammation, promotes epithelialization, and enhances ocular surface healing without the need for surgery or external rings, offering a more comfortable and effective treatment option for ocular surface disorders.

Implementation Method 1

a biodegradable carrier material and an active ingredient comprising an amniotic extract and/or placental extract

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 2

biodegradable carrier material...controlled degradation rate

Methodology Applied

Scientific EffectBiodegradation: Decomposition (biological)

Data Source

PatentUS11628189B2Amniotic or placental device for ophthalmic use as a dressing with refractory center section

Publication Date: 2023.04.18 CETEL SCI LLC

AI summary

A biodegradable lens-shaped patch useful for healing and treatment of ocular conditions is disclosed. The patch is formed from a biodegradable carrier which carries amniotic extract and/or placental extract. The lens-shaped patch may be shaped in the form of a conventional contact lens and it is applied to a corneal surface to enhance healing thereof. After a certain period of time, the patch dissolves on its own and it need not be removed from the eye by a clinician. In an embodiment, the patch includes a clear central section that may be refractory, and a biodegradable peripheral section.