Biodegradable Delivery Particles With Cross-Linked Leakage Control
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Solution Overview
Problem
Existing microencapsulation technologies face challenges in achieving complete retention of encapsulated active ingredients throughout the supply chain, especially in harsh environments, while ensuring biodegradability and stability, particularly in aqueous surfactant-based compositions, with limited options that are safe for both environmental and human health.
Innovation Solution
Development of biodegradable delivery particles with a core encapsulated in a polymer wall formed by radical polymerization of water-soluble hydroxyl-containing linear carbon-chain polymers and multifunctional (meth)acrylate monomers, enhanced by the use of partitioning modifiers to maintain structural integrity and prevent leakage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-generated harmful factors
If biodegradable materials are used to form delivery particles, then environmental safety and biodegradability are improved, but structural integrity and leakage resistance deteriorate
Solution Approach 1:
The patent employs composite wall structures combining biodegradable polymers (chitosan, polyvinyl alcohol) with cross-linking agents (glutaraldehyde, genipin) to create a material system that achieves both biodegradability and enhanced structural integrity. The cross-linked network provides mechanical strength while the biodegradable polymer matrix maintains environmental safety.
Solution Approach 2:
The patent modifies the chemical and physical parameters of biodegradable polymers through controlled cross-linking degree, molecular weight selection, and polymer concentration optimization. These parameter changes enable the material to simultaneously achieve sufficient structural integrity for leakage resistance and maintain biodegradability for environmental safety.
2Reliability
If delivery particles are designed for high structural integrity to reduce leakage, then retention of benefit agent is improved, but biodegradability deteriorates
Solution Approach 1:
The patent optimizes cross-linking density and polymer composition parameters to achieve a balanced state where the wall structure provides sufficient retention of benefit agents while maintaining可控 biodegradability. The cross-linking degree is controlled to be high enough for retention but not so high as to prevent complete degradation.
Solution Approach 2:
The patent extracts and utilizes specific functional groups (hydroxyl, amine) from natural polymers that can form reversible cross-links or hydrogen bonds, providing temporary structural integrity for retention while allowing complete breakdown and biodegradation when these weak interactions are disrupted by environmental conditions.
3Duration of action of moving object
If mechanical rupture is used as release mechanism, then controlled release of benefit agent is achieved, but premature release due to mechanical stress before desired time occurs
Solution Approach 1:
The patent applies preliminary cross-linking treatment to the polymer wall before encapsulation, pre-establishing a stable network structure that resists premature mechanical rupture. This preliminary reinforcement ensures the particles can withstand supply chain mechanical stresses without releasing the benefit agent before the desired time.
Solution Approach 2:
The patent incorporates flexible polymer segments and controlled free volume within the cross-linked wall structure that act as cushioning elements, absorbing mechanical stresses and preventing stress concentration that would lead to premature rupture. This beforehand cushioning protects the encapsulated benefit agent from early release.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The delivery particles provide high structural integrity and biodegradability, effectively protecting benefit agents in harsh environments and ensuring controlled release, while maintaining stability in aqueous surfactant-based compositions.
Implementation Method 1
a wall formed by a radical polymerization reaction between: a water soluble hydroxyl containing linear carbon-chain polymer comprising 1,2-diol and/or 1,3-diol functionality; a multifunctional (meth)acrylate monomer and/or oligomer
Data Source
AI summary
A biodegradable delivery particle having a benefit agent containing core and a shell.