Biodegradable Polymer Inorganic Peroxide Oxygen Delivery
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Solution Overview
Problem
Current methods for treating hypoxic tissue, such as those used in tissue engineering, face limitations in oxygen diffusion, leading to necrosis in transplanted cells and tissues, especially in large volumes, with partial success from oxygen-rich fluids and angiogenic factors.
Innovation Solution
A method and composition using a biodegradable polymer incorporating inorganic peroxide in solid form, optionally with a radical trap or decomposition catalyst, to enhance oxygenation of hypoxic tissues, which can be administered as a sheet, microparticles, or spray, facilitating healing in wounds, treating infections, or addressing cancer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If oxygen rich fluids such as perfluorocarbons and silicone oils are used to treat hypoxic tissue, then oxygen supply to tissue is improved, but the method only partially succeeds in achieving survival of clinically applicable large tissue mass
Solution Approach 1:
The invention changes the chemical form of oxygen delivery from dissolved oxygen in fluids to chemically bound oxygen in organic peroxide molecules. This parameter change allows oxygen to be stored in a stable, concentrated form and released on-demand through decomposition, providing more reliable and sustained oxygen supply to large tissue volumes compared to oxygen-rich fluids.
Solution Approach 2:
The invention uses composite materials consisting of organic peroxide compounds combined with biodegradable polymers or carriers. This composite approach allows the oxygen-carrying peroxide to be delivered and retained in target tissues, providing both oxygen supply and structural support, thereby improving tissue survival rates in large-volume implants.
2Volume of stationary object
If large volumes of cell or tissue components are implanted, then the clinical applicability is improved, but oxygen diffusion limitations lead to necrosis
Solution Approach 1:
The invention applies preliminary action by incorporating oxygen-generating organic peroxides into the tissue implant before transplantation. This pre-loading of oxygen ensures that adequate oxygen is available from the moment of implantation, preventing necrosis in large-volume implants where diffusion from external sources would be insufficient.
Solution Approach 2:
The organic peroxide compounds in the invention enable the implanted tissue to serve itself by generating oxygen internally through peroxide decomposition. This self-service mechanism eliminates dependence on external oxygen diffusion, allowing large tissue volumes to survive without requiring immediate establishment of blood supply.
3Use of energy by moving object
If angiogenic factors such as VEGF are used to maintain tissue viability, then oxygenation is partially improved, but the method has only partial success in achieving survival of large tissue mass
Solution Approach 1:
The invention uses organic peroxide compounds as intermediary oxygen carriers that directly deliver oxygen to tissue cells without requiring the complex biological pathway of angiogenesis. This intermediary approach provides immediate and reliable oxygenation, bypassing the time-consuming and unreliable process of new blood vessel formation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of biodegradable polymers with inorganic peroxides delays necrosis, improves tissue survival, and supports oxidative metabolism, as demonstrated by reduced lactate levels and preserved tissue architecture, while also treating anaerobic infections and cancer.
Implementation Method 1
the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer
Implementation Method 2
an inorganic peroxide incorporated into the polymer in solid form
Implementation Method 3
optionally a radical trap or decomposing catalyst incorporated into and/or onto the polymer in solid form
Data Source
AI summary
A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.