Biodegradable Polymer Dispersion for Controlled Skin Delivery
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Solution Overview
Problem
Existing active ingredient delivery systems, such as nanoparticles and colloids, face challenges in effectively penetrating the skin barrier layer, leading to poor absorption, excessive initial release, and difficulty in controlling the release rate, especially for high molecular weight ingredients.
Innovation Solution
A biodegradable polymer dispersion comprising a lactic acid-based polymer, a block copolymer of lactic acid and polyethylene glycol, and high molecular weight hyaluronic acid, with specific weight ratios and particle sizes, allows for controlled delivery and continuous release of active ingredients across the skin barrier.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional nanoparticles (liposome, cationic polymers, quantum dots, magnetic particles, gold nanoparticles) are used for active ingredient delivery, then cell absorption is promoted, but cytotoxicity occurs, effective delivery is difficult, and biodegradability is lacking
Solution Approach 1:
The patent uses a composite delivery system comprising biodegradable polymer nanoparticles (PLA or PLGA) encapsulating active ingredients, combined with hyaluronic acid and PEG-block-copolymer surfactants. This composite structure provides biodegradability, reduced cytotoxicity, and controlled release capabilities while maintaining effective skin penetration and cell absorption promotion.
2Stability of the object's composition
If biodegradable polymer is used to enclose active ingredient, then biodegradability and controlled release are achieved, but high molecular weight active ingredients are difficult to control and show excessive initial release
Solution Approach 1:
The patent optimizes the molecular weight parameters of the biodegradable polymer (PLA or PLGA with specific weight average molecular weights), the ratio of polymer to surfactant, and the particle size distribution to control the release kinetics. These parameter adjustments reduce excessive initial release while maintaining controlled sustained release for high molecular weight active ingredients.
Solution Approach 2:
The patent creates a core-shell structure where the biodegradable polymer forms the core matrix for encapsulation, while the PEG-block-copolymer and hyaluronic acid form the shell layer. This local differentiation allows the core to provide controlled release while the shell enhances stability and reduces initial burst release.
3Reliability
If active ingredient is delivered through skin barrier layer, then percutaneous absorption is improved, but penetration to deep tissues is difficult without physical or chemical promoters
Solution Approach 1:
The patent uses hyaluronic acid and PEG-block-copolymer as intermediary substances that facilitate active ingredient penetration through the skin barrier. These intermediaries reduce surface tension and enhance permeation without requiring complex physical methods like micropore formation or iontophoresis, simplifying the overall delivery system.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biodegradable polymer dispersion exhibits excellent dispersion stability, effectively delivers both hydrophilic and hydrophobic active ingredients, promoting skin penetration and continuous release, enhancing skin regeneration and wound healing effects.
Implementation Method 1
Liposome has a benefit of easy design so that it has a targeting performance as a physical self-assembly, but has poor colloid stability of a delivery system, and is mainly dependent on delivery of an active ingredient by diffusion in the skin barrier layer.
Implementation Method 2
Liposome has a benefit of easy design so that it has a targeting performance as a physical self-assembly, but has poor colloid stability of a delivery system
Data Source
Figure 1(a)~2(b)
Figure 3(a)~4(c)
Figure 5~6
AI summary
The present invention relates to a biodegradable polymer dispersion comprising: a lactic acid-based polymer, a block copolymer including a lactic acid-based polymer and polyethylene glycol, and a high molecular weight hyaluronic acid, and a method for preparing the same. The polymer dispersion allows effective support of functional active ingredients, exhibits excellent physiological activity on its own upon penetration into the skin, and has significantly improved dispersion stability to provide an excellent delivery effect to tissues.