Biodegradable Polymer Wound Dressing for Controlled Anabolic Agent Release
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Solution Overview
Problem
Current wound healing technologies face challenges in efficiently enhancing wound healing rates, particularly due to issues with adhesive removal and tissue growth into wound dressings, and the lack of effective local administration of anabolic agents for wound healing.
Innovation Solution
Development of an implantable medical device comprising an anabolic agent and biodegradable polymers that release the anabolic agent over a controlled period, either through a drug depot or topical formulation, to enhance wound healing by promoting tissue growth and reducing tissue irritation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If wound dressings are held in place by sutures or adhesives, then the dressing stays in place during healing, but the removal process causes tissue injury and delays healing
Solution Approach 1:
The patent extracts the harmful adhesive/suture components from the wound dressing system and replaces them with a biodegradable polymer matrix that naturally degrades and is absorbed by the body, eliminating the need for removal and associated tissue injury
Solution Approach 2:
The biodegradable polymer matrix performs self-service by automatically degrading and being absorbed by the body over time, providing continuous wound coverage without requiring external intervention for removal, thus preventing tissue injury
2Quantity of substance
If anabolic agents are administered systemically, then the agents are distributed throughout the body, but this causes unnecessary systemic side effects and reduces local wound healing efficiency
Solution Approach 1:
The patent applies local quality by incorporating anabolic agents directly into the biodegradable polymer wound dressing, enabling localized delivery to the wound site only, which prevents systemic distribution and associated side effects while concentrating the therapeutic effect where needed
Solution Approach 2:
The biodegradable polymer matrix serves as an intermediary carrier that localizes the anabolic agent at the wound site, controlling its release and preventing systemic distribution, thus acting as a mediator between the drug and the target tissue
3Duration of action of stationary object
If wound dressings are removed after healing, then the dressing has served its purpose, but tissue grows into the dressing causing injury during removal
Solution Approach 1:
The biodegradable polymer matrix performs self-service by automatically degrading into smaller molecules that are naturally absorbed and metabolized by the body over time, eliminating the need for removal and preventing tissue entanglement and injury
Solution Approach 2:
The patent applies parameter changes by designing the polymer matrix with specific biodegradation properties that change its physical state over time from an intact structure to degraded molecules, allowing it to maintain wound coverage during healing then naturally dissolve without causing tissue injury
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The controlled release of anabolic agents accelerates wound healing by promoting tissue growth and reducing healing time, while minimizing tissue irritation and the need for invasive removal methods.
Implementation Method 1
an implantable medical device comprising an anabolic agent, and at least one biodegradable polymer, the medical device having a surface that releases (i) about 5% to about 45% of the anabolic agent relative to a total amount of the anabolic agent loaded in the medical device over a first period of up to 48 hours and (ii) about 55% to about 95% of the anabolic agent relative to a total amount of the anabolic agent loaded in the medical device over a subsequent period of at least 3 days
Data Source
AI summary
Improved medical devices and methods are provided comprising an anabolic agent for wound healing. These improved medical devices and methods can enhance wound healing in wounds from cuts, abrasions, lesions, burns including sunburn, surgical incisions, pressure ulcers, diabetic ulcers, traumatic wounds, or other injuries or maladies, which can be chronic or non-chronic in origin. In some embodiments, the medical device comprises a drug depot that releases the anabolic agent over at least 3 days to enhance wound healing.