Biodetector Functionalized Surface Abrasion Protection
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Solution Overview
Problem
Existing biodetectors face issues with the functionalized surface being prone to abrasion and requiring biocompatibility tests, as the surface can be easily rubbed off during insertion or removal from the body, and there's a risk of triggering defensive reactions.
Innovation Solution
A biodetector design with a functionalized surface that protects the surface from abrasion by containing it within an interior space, using detection molecules like monoclonal antibodies, and incorporating a liquid removal section made from biocompatible materials to control fluid absorption and prevent backflow, allowing for controlled enrichment and analysis of target molecules and cells without returning body fluid to the body.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the functionalized surface is used to isolate and enrich target molecules and cells, then the detection capability is improved, but the surface is easily rubbed off during insertion and removal from the body
Solution Approach 1:
The biodetector is divided into distinct functional sections: a liquid removal section (cannula) for fluid extraction, a functionalized section with detection molecules for target enrichment, and a detection section. This segmentation allows the functionalized surface to be protected within the device structure while maintaining its detection function.
Solution Approach 2:
The functionalized surface with detection molecules is nested within the biodetector structure, specifically within the interior space defined by the liquid removal section. This nesting protects the functionalized surface from external abrasion during insertion and removal while allowing it to contact body fluid for detection.
2Measurement precision
If the functionalized surface contains detection molecules for target enrichment, then the detection sensitivity is improved, but biocompatibility issues and defensive reactions may occur
Solution Approach 1:
The body fluid containing target molecules and cells is extracted from the body through the liquid removal section and contained within the biodetector's interior space. This extraction allows the functionalized surface with detection molecules to contact and enrich targets outside the body's circulation, enabling the use of non-human detection molecules without triggering defensive reactions in the body.
Solution Approach 2:
The biodetector acts as an intermediary device between the body and the detection process. It removes a specific quantity of body fluid, allowing detection molecules to interact with targets in a controlled environment, and prevents the returned fluid from re-entering body circulation, thus mediating between detection needs and biocompatibility requirements.
3Adaptability or versatility
If body fluid is removed and analyzed outside the body, then the use of non-human detection molecules is enabled, but the device complexity increases
Solution Approach 1:
The biodetector is designed as a multi-functional device that combines liquid removal (via the cannula), target enrichment (via the functionalized surface with detection molecules), and detection capabilities in a single integrated structure. This universality allows the device to perform multiple functions while maintaining a relatively simple overall design based on standardized components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biodetector effectively reduces abrasion risks, eliminates the need for biocompatibility tests, and enables efficient enrichment and analysis of target molecules and cells with improved biocompatibility, allowing for the use of non-human detection molecules and modular components for easy handling and analysis.
Implementation Method 1
The functionalized surface is occupied at least in sections with detection molecules or a receptor or ligand. This allows selected target molecules and target cells to be easily enriched.
Implementation Method 2
The liquid removal section includes an opening through which the liquid enters the interior of the biodetector. The inner space of the liquid extraction portion communicates with the opening. As a result, the liquid removal section itself can already take up a certain amount of liquid.
Data Source
Figure 1~3
AI summary
The invention relates to a biodetector having a functionalised surface for isolating molecules or cells from the human body. In order to improve a biodetector of the kind mentioned above such that the functionalised surface of the biodetector, or molecules or cells accumulated thereon, are subjected to less abrasion and the biocompatibility of the biodetector is improved, the biodetector is designed to remove a liquid from the human body and to receive it in an inner chamber of the biodetector, wherein the functionalised surface faces the inner chamber of the biodetector.