Bioelectric Stimulator Modulating Sestrin Expression
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Solution Overview
Problem
Current methods lack the ability to precisely modulate the expression and release of sestrins, which are stress-responsive proteins with anti-aging properties, in cellular tissue for therapeutic applications.
Innovation Solution
A bioelectric stimulator is developed to produce specific bioelectric signals, including biphasic constant currents at 10-20 Hz frequencies and 300-400 microseconds pulse widths, to upregulate or downregulate sestrin expression in target tissues, using electrodes to deliver these signals for 5 minutes to an hour.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods are used, then no modulation of sestrin expression is achieved, but the ability to treat age-associated pathologies and metabolic disorders is lost
Solution Approach 1:
The patent applies parameter changes by using specific bioelectric signal parameters (frequency, pulse width, amplitude) to modulate sestrin expression. Different signal parameters are used to achieve different therapeutic effects, enabling both reliable sestrin modulation and broad therapeutic versatility for treating age-associated pathologies, metabolic disorders, and other conditions
2Productivity
If no specific bioelectric signal is applied, then device complexity is minimized, but productivity in terms of sestrin modulation efficiency is reduced
Solution Approach 1:
The device incorporates pre-programmed signal protocols that have been optimized in advance for specific therapeutic outcomes. This preliminary action allows the device to achieve high sestrin modulation efficiency without requiring complex real-time programming, as the effective parameters are predetermined and stored in the device
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bioelectric stimulator effectively increases sestrin expression by up to 190% in various tissue types, demonstrating potential for anti-aging, muscle health, cardiovascular protection, and treatment of various diseases, while also allowing for the modulation of other biological molecules.
Implementation Method 1
administering the bioelectric signal to the living cells via the electrode(s) for from about 5 minutes to about an hour, so as to modulate the expression of sestrins by the living cells
Data Source
AI summary
Described is a low voltage, pulsed electrical stimulation device for modulating the expression of sestrin, a useful protein, by tissues. Also described are methods of enhancing expression of sestrins in cells, particularly a method of stimulating the expression and/or release of sestrins in a cell having a gene encoding a sestrin, wherein the method includes applying a bioelectric signal comprising a biphasic constant current at a frequency of, within 15%, 10 Hz to 20 Hz, with a pulse width of, within 15%, 300 to 400 microseconds (μsec).