Bioenvironmental Simulation Device for Hypertensive Cell Studies
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Solution Overview
Problem
Current methods for simulating a hypertensive environment for cell studies are either damaging to cells, have low reproducibility, or are excessively costly due to complex device structures, and fail to accurately replicate the in vivo conditions by not considering individual cell types.
Innovation Solution
A bioenvironmental simulation device that applies constant pressure through rotational force and shear force to cells using a culture liquid flow system, with independent flow rates and controlled rotational speeds to mimic in vivo conditions, allowing for precise simulation of blood pressure and flow rates.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If chemical methods are used to damage cells for simulating hypertensive environment, then the hypertensive environment can be simulated, but cell damage is caused by drugs
Solution Approach 1:
The patent replaces chemical methods with a mechanical system consisting of a rotational force application part and a culture liquid flow device. The rotational force application part applies centrifugal force to simulate blood pressure, while the culture liquid flow device applies shear force through flowing culture liquid, thereby mechanically simulating the hypertensive environment without using harmful chemical drugs
Solution Approach 2:
The patent uses hydraulic principles by circulating culture liquid through the culture liquid flow device to apply shear force to cells. The flow of culture liquid creates a shear stress environment that mimics in vivo conditions, replacing chemical damage methods with fluid mechanical effects
2Reliability
If direct force application method is used to simulate hypertensive environment, then the hypertensive environment can be simulated, but the device has complex structure and occupies lot of installing space
Solution Approach 1:
The patent merges the pressure application function and shear force application function into a single integrated device structure. The rotational force application part and culture liquid flow device work together in a compact arrangement, eliminating the need for separate complex equipment and reducing installation space while maintaining simulation accuracy
Solution Approach 2:
The device structure serves multiple functions: the rotational force application part applies centrifugal force for pressure simulation, while the culture liquid flow device simultaneously applies shear force. This multi-functionality reduces the need for separate dedicated equipment, simplifying the overall device structure
3Ease of operation
If pressure is applied to cells without considering types of each individual cell, then the procedure is simple, but the hypertensive environment cannot be accurately simulated
Solution Approach 1:
The patent enables dynamic adjustment of simulation parameters including rotational speed of the rotational force application part and flow rate of the culture liquid flow device. This allows the system to be adapted to different cell types and experimental requirements while maintaining ease of operation through straightforward parameter control
Solution Approach 2:
The patent allows independent adjustment of key parameters such as rotational speed and culture liquid flow rate to control the magnitude of applied forces. By changing these parameters, the system can be optimized for different cell types and experimental conditions, achieving both operational simplicity and simulation accuracy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables stable and reproducible simulation of hypertensive environments without cell damage, allowing for accurate study of cellular responses and potential drug development, while being cost-effective and easy to operate.
Implementation Method 1
a rotational force application part configured to rotate the mounting unit so as to apply a rotational force to the cells to be measured placed on the mounting unit
Implementation Method 2
the culture liquid flows by the culture liquid flow device so as to apply a shear force to the cells to be measured
Data Source
AI summary
The bioenvironmental simulation device according to an embodiment of the present invention includes at least one mounting unit on which cells to be measured are placed, a rotational force application unit configured to rotate the mounting unit so as to apply a rotational force to the cells to be measured placed on the mounting unit, and a culture liquid flow device through which a culture liquid flows across the mounting unit, wherein the culture liquid flows by the culture liquid flow device so as to apply a shear force to the cells to be measured.