Bioeroding Cannabinoid Edible Composition for Oral Absorption
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Solution Overview
Problem
Current methods of delivering cannabinoids, such as ingestion and inhalation, face limitations for individuals with swallowing difficulties or lung irritation, and have issues with efficacy due to malabsorption and molecular modifications.
Innovation Solution
A composition containing botanical drug substances, such as cannabinoids, is formulated into a moldable edible article that bioerodes in the oral cavity or gastrointestinal tract, allowing buccal, sublingual, or systemic absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cannabinoids are delivered through traditional ingestion methods (syrups, tablets, films), then the delivery system is simple and easy to manufacture, but bioavailability is reduced due to malabsorption and first-pass liver effects
Solution Approach 1:
The patent uses a biodegradable polymer matrix as an intermediary carrier that protects cannabinoids from gastrointestinal degradation and facilitates their absorption. The polymer matrix acts as a protective medium that prevents direct contact with digestive enzymes while enabling controlled release and absorption, thereby improving bioavailability without requiring complex delivery systems.
Solution Approach 2:
The patent modifies the physical and chemical parameters of the delivery system by incorporating biodegradable polymers with specific molecular weights and degradation rates. By controlling parameters such as polymer composition, molecular structure, and degradation characteristics, the system enhances cannabinoid bioavailability while maintaining reasonable system complexity.
2Speed
If cannabinoids are delivered through inhalation of smoke, then rapid absorption is achieved, but lung irritation and adverse health effects occur
Solution Approach 1:
The biodegradable polymer matrix serves as an intermediary that enables rapid absorption without requiring inhalation. The polymer-based formulation can be administered through methods that avoid lung exposure, such as oral delivery or transdermal application, thereby maintaining rapid absorption speed while eliminating lung irritation associated with smoke inhalation.
Solution Approach 2:
The patent replaces the mechanical inhalation process with alternative administration methods that utilize the biodegradable polymer matrix for rapid absorption. This substitution eliminates the harmful mechanical action of smoking while preserving the rapid absorption characteristic through controlled polymer degradation and cannabinoid release.
3Ease of manufacture
If individuals with phagophobia or dysphagia swallow solids or liquid dosage forms, then the delivery method is straightforward, but administration becomes difficult or impossible
Solution Approach 1:
The patent changes the physical parameters of the dosage form by using biodegradable polymers that can be formulated in various forms (capsules, tablets, liquids, or topical applications) suitable for different patient needs. This flexibility allows the same active ingredient to be delivered in a form that is easy to manufacture while being appropriate for patients with swallowing difficulties, thereby improving both ease of manufacture and ease of operation.
4Device complexity
If cannabinoids undergo molecular modifications during gastrointestinal processing, then the delivery pathway is simple, but efficacy is reduced due to malabsorption
Solution Approach 1:
The biodegradable polymer matrix acts as a protective intermediary that shields cannabinoids from gastrointestinal enzymes and chemicals that would cause molecular modifications and malabsorption. This protective medium maintains the integrity of the cannabinoid molecules during transit through the gastrointestinal tract, thereby preserving efficacy while keeping the delivery pathway relatively simple.
Solution Approach 2:
The patent applies preliminary protection to the cannabinoids by incorporating them within the biodegradable polymer matrix before they enter the gastrointestinal tract. This preliminary action prevents harmful molecular modifications from occurring during digestion, thereby maintaining cannabinoid efficacy while requiring only a simple delivery pathway.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances bioavailability of cannabinoids by providing a chewable and ingestible delivery method that bypasses gastrointestinal tract malabsorption and liver first-pass effects, suitable for individuals with swallowing difficulties.
Implementation Method 1
an edible article which can bioerode upon oral administration to buccally, sublingually, or by system absorption
Implementation Method 2
a composition which can entrain a cannabinoid while remaining moldable for production of an edible article
Data Source
AI summary
Generally, a composition and methods of making a composition and an edible article from the composition. Specifically, a composition containing a botanical drug substance and methods of making and using an edible article from the composition for delivery of a dose of the botanical drug substance.