BioFET Sensor Array for Rapid Target Material Identification
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Solution Overview
Problem
Current biosensors that incorporate transistors for detecting biomolecules face challenges in efficiently identifying target materials due to limitations in sensitivity and detection speed, particularly in multi-assay setups where multiple probes are required for accurate identification.
Innovation Solution
A bio-sensing integrated circuit with a sensor array is developed, featuring a BioFET structure and a sensing layer that uses cross-linkers and probes to detect target materials by measuring changes in channel conductance, allowing for simultaneous coating and calibration of multiple assays to enhance testing efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple probes are used for accurate target material identification in multi-assay setups, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The sensor array is divided into multiple independent sensing elements, each functionalized with different probes for specific target materials. This segmentation allows parallel detection of multiple analytes while maintaining individual probe specificity, resolving the contradiction between measurement precision and device complexity by organizing complexity into modular, manageable units
Solution Approach 2:
A single sensor array platform performs multiple detection functions by incorporating different probe types on different sensing elements. The universal platform architecture allows one device to simultaneously execute multiple assays for different target materials, eliminating the need for separate devices for each assay and reducing overall system complexity while maintaining high measurement precision
2Reliability
If traditional biosensing methods are used for target material detection, then detection capability is achieved, but loss of time increases due to sequential processing requirements
Solution Approach 1:
Multiple sensing elements in the array operate simultaneously and continuously to detect different target materials. The parallel architecture enables continuous detection across all assay channels at the same time, eliminating sequential processing delays and reducing total experimental time while maintaining reliable detection capability across all targets
Solution Approach 2:
The sensing elements are pre-functionalized with specific probes before sample introduction, preparing multiple detection channels in advance. This preliminary action allows immediate parallel detection upon sample application, eliminating the need for sequential probe attachment or preparation steps and significantly reducing overall detection time while ensuring detection reliability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables rapid and accurate identification of target materials by reducing experimental time to 15 minutes or less, improving detection precision through simultaneous processing of multiple assays with different probes, thereby enhancing testing efficiency.
Implementation Method 1
detect target materials by measuring changes in channel conductance
Implementation Method 2
uses cross-linkers and probes to detect target materials
Data Source
AI summary
A target material identification method includes the following steps. A bio-sensing integrated circuit having a sensor array is provided. The sensor array is divided into 1st-Nth assays, and the 1st-Nth assays are coated with different probes. A calibration process is performed to obtain 1st-Nth pre-test measurement values respectively for the 1st-Nth assays. A sample fluid having the target material therein is provided onto the 1st-Nth assays. A bio-sensing process is performed on the sample fluid to obtain 1st-Nth post-test measurement values respectively for the 1st-Nth assays. The 1st-Nth pre-test measurement values are compared with the corresponding 1st-Nth post-test measurement values, so as to determine whether the target material is bind to the probes in each of the 1st-Nth assays. An assay having the target material bind to the probe is marked as a binding assay. The target material is identified based on the probe in the binding assay.