Biopsy Instrument with Biofunctionalized Spring-Elastic Guide
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Solution Overview
Problem
Current biopsy instruments are inadequate for efficiently enriching cellular or molecular samples from body cavity systems, often causing injury, being complex to use, and are not suitable for endoscopic applications, with limited precision and high costs.
Innovation Solution
A biopsy instrument comprising a spring-elastic guide member with a biofunction element and stabilizing element, where the biofunction element has detection molecules on its surface for specific enrichment of samples from various body cavity systems, minimizing risk of injury and ensuring complete removal of the instrument.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional biopsy instruments are used for sample removal, then tissue samples can be obtained, but the samples are not enriched and require large volumes for diagnosis
Solution Approach 1:
The biofunction element is positioned at the distal end of the guide element before insertion into the body cavity. It performs preliminary enrichment of cellular or molecular samples in situ within the body cavity, concentrating target materials before they are withdrawn for diagnostic analysis. This preliminary action eliminates the need for large sample volumes and subsequent complex enrichment procedures.
2Ease of operation
If suction means are used to retain samples in the needle, then samples can be held during withdrawal, but the instrument structure becomes complex and requires considerable skill to handle
Solution Approach 1:
The complex suction means and stylet mechanisms are removed from the instrument. Instead, a simple guide element with a biofunction element is used, which relies on the adhesion properties of the biofunction element to retain enriched samples during withdrawal. This extraction of complex components dramatically simplifies the instrument structure and ease of operation.
3Reliability
If sharp frontal edges or notched stylets are used to cut tissue, then tissue segments can be obtained, but the samples may be crushed and tension is applied during removal
Solution Approach 1:
The mechanical cutting system with sharp edges and notched stylets is replaced by a biofunction element that enriches samples through molecular recognition and adhesion. The guide element withdraws smoothly without mechanical cutting action, eliminating crushing forces and tension on the samples. This substitution of mechanical cutting with biochemical enrichment preserves sample integrity.
4Ease of manufacture
If functionalism surfaces are used for enrichment, then specific cells or molecules can be enriched in situ, but no suitable biopsy instrument embodiment has been described for manufacturing
Solution Approach 1:
The guide element is designed with a specific distal end portion that incorporates the biofunction element with detecting molecules. This local quality concentration at the distal end enables targeted enrichment of specific cellular or molecular samples in situ within the body cavity, while the rest of the instrument remains structurally simple and manufacturable.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The instrument enables accurate, specific, and sensitive enrichment of samples with reduced risk of injury, ease of handling, and low cost, facilitating rapid and reliable diagnostic procedures.
Implementation Method 1
The guide element has a distal and a proximal portion, wherein the distal portion is designed to be spring-elastic
Implementation Method 2
a biofunction element (4), which is placed between the distal and proximal portion of the guide element (1), and which has detecting molecules on its surface
Data Source
AI summary
The present invention relates to a biopsy instrument, comprising the following components: i. a guide element (1) comprising a spring-elastic distal (2) region and a proximal (3) region; ii. a biofunctionalized element (4) arranged between the distal and the proximal region of the guide element and whose surface has detection molecules, and iii. a stabilizing element (5) connected to the proximal region of the guide element. The invention further relates to the use of said biopsy instrument for enriching specific sample material from the body as well as to a biopsy kit and the use of the same for enriching specific sample material.