Bioimplant Silver-Infused Coating Sustained Ion Release
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Solution Overview
Problem
Conventional bioimplants fail to inhibit biofilm formation over a long period after surgery, leading to high risks of post-operative infections, especially in patients with weakened immune systems or autoimmune diseases, as antimicrobial agents lose effectiveness.
Innovation Solution
A bioimplant with a thermal spraying film of calcium phosphate-based material, containing 0.05 wt% to 3.00 wt% silver, applied to a metal, ceramic, or plastic substrate, which inhibits biofilm formation by controlling the release of silver ions, thereby maintaining antimicrobial efficacy for an extended period.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If a hydroxyapatite coating film with uniform pore size and porosity is used for antibiotic impregnation, then the coating can be easily prepared, but the medicine release rate cannot be controlled and tends to be eluted at a fixed rate at a time
Solution Approach 1:
The patent employs a hydroxyapatite coating film with controlled porosity and pore size to enable sustained release of antimicrobial agents. The porous structure allows the coating to be impregnated with antibiotics while controlling the release rate through its pore characteristics, resolving the contradiction between ease of preparation and controlled duration of action.
Solution Approach 2:
The patent modifies the physical and chemical parameters of the hydroxyapatite coating, including porosity, pore size, and crystallinity, to control the release rate of antimicrobial agents. By adjusting these parameters, the coating can provide sustained release over periods ranging from several days to several weeks, rather than fixed-rate elution.
2Device complexity
If conventional bioimplants are used without long-term antimicrobial coating, then the implant structure remains simple, but post-operative infection risk increases due to biofilm formation
Solution Approach 1:
The patent creates a composite structure by combining a base implant material with a hydroxyapatite coating layer that contains embedded antimicrobial agents. This composite approach provides long-term infection resistance through sustained antibiotic release while maintaining relative simplicity of the overall implant structure.
Solution Approach 2:
The hydroxyapatite coating acts as an intermediary layer between the implant and the biological environment, providing sustained release of antimicrobial agents to prevent biofilm formation. This intermediary coating protects the implant from infection without requiring complex structural modifications to the base implant.
3Duration of action of moving object
If the hydroxyapatite coating is designed for sustained release, then the antimicrobial activity duration is extended, but the manufacturing process becomes more complex
Solution Approach 1:
The patent utilizes the natural porous structure of hydroxyapatite coatings to achieve sustained release of antimicrobial agents. By controlling the porosity and pore size during coating formation, the patent extends antimicrobial activity duration without requiring overly complex multi-layer or multi-component structures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bioimplant effectively reduces the risk of post-operative infections by inhibiting biofilm formation for several weeks after surgery, particularly in high-risk patients, by sustained release of silver ions, thereby ensuring prolonged antimicrobial activity.
Implementation Method 1
by controlled release of silver ions
Implementation Method 2
the silver concentration in the thermal spraying film being 0.05 wt % to 3.00 wt %
Implementation Method 3
a thermal spraying film made of a calcium phosphate-based material formed on at least a portion of a metal, ceramic or plastic substrate
Implementation Method 4
formed on at least a portion of a metal, ceramic or plastic substrate
Data Source
AI summary
Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %.