Biologic Fluid Analysis Cartridge with Capillary Flow Control
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Solution Overview
Problem
Existing biologic fluid analysis techniques require sample dilution and fluid flow, which limits their accuracy and reliability, and are not cost-effective for evaluating undiluted samples.
Innovation Solution
A biologic fluid analysis cartridge with a sample handling portion and an analysis chamber portion, featuring a collection port, initial channel, secondary channel, and ante-chamber, which allows for selective fluid communication and prevents capillary flow into the analysis chamber without sample dilution, enabling accurate analysis of undiluted samples.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If impedance or optical flow cytometry is used to analyze biologic fluid samples, then constituents within the sample can be evaluated, but sample dilution and fluid flow handling apparatus are required
Solution Approach 1:
The patent extracts the fluid flow handling requirement from the analysis system by using capillary action to automatically draw diluted sample through the analysis chamber without pumps or flow control mechanisms. The channel geometry itself provides the flow control, eliminating complex fluid handling apparatus while maintaining analysis accuracy.
Solution Approach 2:
The system uses self-service by relying on capillary action to automatically draw the diluted sample through the analysis chamber. The channel dimensions and surface properties are designed to provide sufficient capillary force to move the sample without external pumping, making the system self-actuating and eliminating the need for complex fluid handling apparatus.
2Reliability
If undiluted biologic fluid is analyzed using traditional smear techniques, then cell integrity can be maintained, but results depend largely on technician experience and technique
Solution Approach 1:
The patent changes the physical parameters of the sample by diluting it with a buffer solution before analysis. This dilution reduces cell concentration to an optimal range for imaging while maintaining cell integrity, and the standardized dilution process eliminates variability introduced by technician skill levels.
Solution Approach 2:
The patent replaces the mechanical smear technique with an automated imaging system. Instead of manually smearing undiluted sample on a slide, the system uses capillary action to draw diluted sample through a channel and captures images with a camera, replacing technician-dependent mechanical operations with automated optical measurement.
3Measurement precision
If flow cytometry techniques are used to evaluate biologic fluid samples, then particulate components can be analyzed, but sample dilution is required
Solution Approach 1:
The patent applies parameter changes by diluting the sample with a buffer solution to achieve optimal particle concentration for imaging analysis. This controlled dilution transforms the sample into a state suitable for accurate particulate component analysis while minimizing sample loss through standardized dilution ratios.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cartridge provides accurate and cost-effective analysis of undiluted biologic fluid samples without the need for fluid flow, enhancing the reliability and efficiency of particulate component analysis.
Implementation Method 1
an air gap which is sized to prevent capillary flow of fluid sample into the chamber
Data Source
AI summary
A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.