Biologic Preserving Composition for Skin Treatment

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Solution Overview

Problem

Current treatments for skin disorders and aging often involve irritating drugs that require weeks to show results and can cause side effects, with limited options for those with sensitive skin, and existing formulations struggle to effectively preserve and prolong the life of biologics like PRP for topical use.

Innovation Solution

A base composition that includes humectants, buffering agents, and viscosity modifying agents, combined with biologics such as PRP, is used to create a topical formulation that extends the life and enhances the stability of biologics for extended periods, allowing for prolonged maintenance and application, including the use of platelet-rich plasma activators to release growth factors into the skin.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional drugs like Retin-A, hydroquinone, glycolic acid, or beta hydroxyl acid are used to improve skin tone and elasticity, then skin improvement results are achieved, but skin irritation, sun sensitivity, peeling, dryness, and acne worsening occur

Engineering Contradiction:

Improveskin improvement effectivenessVSAvoidskin irritation and side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses biologics (platelet-rich plasma, growth factors, stem cells) as intermediary substances that mediate skin repair and regeneration processes. These biologics act as natural mediators that stimulate the skin's own healing mechanisms rather than directly irritating the skin like traditional chemicals, thereby achieving skin improvement without the harmful side effects of conventional treatments

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent employs readily available biologics such as platelet-rich plasma derived from the patient's own blood, which can be prepared locally and applied topically. This approach replaces expensive, long-term commitment to irritating medications with a more sustainable, naturally-derived treatment that the body can process without adverse reactions

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Reliability

If biologics like PRP are used for topical treatment of skin disorders, then skin repair and regeneration are enhanced, but the short shelf life and stability issues of biologics limit their practical application

Engineering Contradiction:

Improvebiologic activity and efficacyVSAvoidbiologic shelf life and stability

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent prepares biologics such as platelet-rich plasma and growth factor concentrates in advance through controlled laboratory processes, then formulates them into stable topical preparations. This preliminary preparation and stabilization allows the biologics to be stored and transported while maintaining their biological activity, extending their usable shelf life from days to months

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent combines biologics with appropriate carriers, stabilizers, and formulation agents to create composite topical preparations. These composite formulations protect the sensitive biologic components from degradation while maintaining their biological activity, effectively extending shelf life and enabling practical topical application

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The formulation effectively maintains and prolongs the activity of biologics like PRP for up to 120 days, providing a safer and more effective treatment for skin disorders and aging without the irritation associated with traditional treatments, improving skin tone and elasticity.

Implementation Method 1

the base compositions include a humectant, sodium bicarbonate, a buffering agent, magnesium chloride, and a viscosity modifying agent

Methodology Applied

Scientific EffectHumectant action: Absorption (physical)

Implementation Method 2

the base compositions include a humectant, sodium bicarbonate, a buffering agent, magnesium chloride, and a viscosity modifying agent

Methodology Applied

Scientific EffectBuffering action:

Implementation Method 3

the base compositions include a humectant, sodium bicarbonate, a buffering agent, magnesium chloride, and a viscosity modifying agent

Methodology Applied

Scientific EffectViscosity modification:

Data Source

PatentUS10588924B1Biologic preserving composition and methods of use

Publication Date: 2020.03.17 AESTHETICS BIOMEDICAL INC

AI summary

Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.