Biologic Sample Container With Septum-Controlled Toxic-Liquid Transfer

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Solution Overview

Problem

Existing containers for biological samples in in vitro diagnostics face risks of exposure to toxic preservative/stabilizer reagents due to inadequate sealing and potential leakage of toxic vapors, leading to health hazards for operators.

Innovation Solution

A container design with a connecting sleeve featuring a transversal septum and multiple transfer openings, along with circumferential projections and a central vent, ensures a tight seal and controlled transfer of toxic liquids, preventing vapor escape and air ingress.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Device complexity

If a simple butt joint is used to connect receptacles, then device complexity is reduced, but sealing reliability deteriorates leading to potential leakage of toxic vapors

Engineering Contradiction:
Improveconnection structureVSAvoidsealing reliability
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

A flexible membrane seals the transfer openings in the septum, creating a reliable seal that prevents toxic vapor leakage while maintaining a relatively simple connection structure between receptacles

Inventive Principle:
Principle #30Flexible shells and thin films

Solution Approach 2:

A septum with transfer openings acts as an intermediary component between receptacles, enabling controlled liquid transfer while maintaining sealing through the flexible membrane, thus resolving the contradiction between simplicity and reliability

Inventive Principle:
Principle #24Intermediary (Mediator)

2Ease of operation

If the upper receptacle is unscrewed to transfer toxic liquid, then liquid transfer is enabled, but vapor escape and air ingress occur

Engineering Contradiction:
Improveliquid transferVSAvoidvapor exposure
Core Design Contradiction:
Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The toxic liquid is extracted from the upper receptacle through sealed transfer openings in the septum, allowing liquid transfer while keeping the toxic vapor contained within the closed system

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The liquid rushes through the transfer openings quickly during the transfer process, minimizing the time the system is in a transitional state where vapor escape could occur, while the flexible membrane ensures continuous sealing

Inventive Principle:
Principle #21Skipping (Rushing through)

3Reliability

If formaldehyde is used as preservative, then sample preservation is effective, but operator health risks increase

Engineering Contradiction:
Improvepreservation effectivenessVSAvoidtoxicity
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The harmful formaldehyde preservative is extracted from the operator's environment by containing it within the sealed lower receptacle system, allowing its continued use for effective preservation while eliminating operator exposure risks

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The sealed container system with controlled transfer mechanisms acts as an intermediary barrier between the toxic formaldehyde and the operator, enabling effective sample preservation while protecting operator health

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The design provides a safe and reliable containment of toxic liquids, minimizing health risks by ensuring airtight sealing and preventing vapor leakage during sample handling and transport.

Implementation Method 1

The lid has a sealed receptacle adapted to contain a preserving agent and a puncturing element actuatable to break the seal

Methodology Applied
Scientific EffectGravity: Gravitation

Data Source

PatentUS12370540B2Container for biologic samples and method for their preservation
Publication Date: 2025.07.29 BICOCCHI ENRICO
  • US12370540B2 patent drawing
  • US12370540B2 patent drawing
  • US12370540B2 patent drawing

AI summary

A container (1) for biologic samples has a lower receptacle (2), an upper receptacle (3) for a toxic liquid (LF) or considered as such, having a radial ring (63), and a connecting sleeve (4) with a circumferential rim (54) and a transversal septum (40), provided with a central vent opening (55) and with a plurality of transfer openings (51) for the transfer of toxic liquid (LF). The toxic liquid (LF) is sealed between the upper receptacle (3) and the transversal septum (40) before unscrewing the upper receptacle until its radial ring (63) touches the circumferential rim (54). When unscrewing the upper receptacle (3), the toxic liquid (LF) reaches and passes through the plurality of transfer openings (51), and air contained in the lower receptacle (2) flows into the upper receptacle (3) through the central vent opening (55), without any exit of gases and liquids from the container (1).