Biological Sample Analysis Device with Rough Bearing Surface for Mechanical Lysis
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Solution Overview
Problem
Current devices for analyzing biological samples are not easily transportable, simple to use, reliable, or inexpensive, particularly for rapid field analysis, as they require bulky equipment and lack a comprehensive approach for concentration, purification, mechanical lysis, separation, and pathogen detection.
Innovation Solution
A portable device with a housing, injection and discharge channels, a filter for separation, a rough bearing surface for mechanical lysis, and a flexible membrane for blocking the opening, allowing for independent modification of filter and lysis characteristics, enabling concentration, purification, mechanical lysis, separation, and amplification within a single chamber.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a complete analysis device is provided, then analysis reliability is improved, but device complexity increases
Solution Approach 1:
The patent merges multiple analysis functions (concentration, purification, mechanical lysis, separation, and amplification) into a single integrated chamber, eliminating the need for multiple separate devices and reducing overall system complexity while maintaining complete analysis capability
Solution Approach 2:
The chamber is designed as a multi-functional unit that can perform concentration, purification, mechanical lysis, separation, and amplification operations within a single space, allowing one device to replace multiple specialized devices
2Ease of operation
If separation and mechanical lysis are dissociated, then ease of operation is improved, but device complexity increases
Solution Approach 1:
The chamber is segmented into distinct functional zones: a first space for concentration and purification, a second space for mechanical lysis, and a third space for separation and amplification. This spatial segmentation allows independent optimization and modification of each function while maintaining overall system integration
3Adaptability or versatility
If filter and bearing surface are independently modifiable, then adaptability is improved, but manufacturing complexity increases
Solution Approach 1:
The filter and rough bearing surface are designed as independently replaceable components within the chamber, allowing users to modify or optimize each component separately based on specific analysis requirements without redesigning the entire device
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device allows for a complete analysis of biological samples, including concentration, purification, mechanical lysis, separation, and detection, while being transportable, simple to use, and cost-effective, with the ability to perform these steps independently and visualize results through transparent components.
Implementation Method 1
A filter separating said chamber into two distinct spaces, so as to define a first space into which said injection channel opens and a second space into which said discharge channel opens, said filter having a porosity suitable for the separation to be carried out
Implementation Method 2
A rough bearing surface having a surface roughness parameter suitable for carrying out a mechanical lysis of said biological species
Implementation Method 3
the mechanical lysis is carried out by shearing between two walls, one of the two walls having a rough bearing surface
Implementation Method 4
said filter comprising at least one part having an elastic deformability sufficient to reach said rough bearing surface during the exertion of a bearing force
Data Source
AI summary
A device for analyzing a biological sample which includes a separation and detection chamber into which an injection channel and a discharge channel open, a filter separating the chamber into two distinct spaces so as to define a first space into which the injection channel opens and a second space into which the discharge channel opens, the filter having a porosity suitable for the separation to be carried out, a rough bearing surface having a surface roughness parameter suitable for carrying out a mechanical lysis of the biological species present in the sample, the bearing surface being arranged in the first space, a flexible membrane arranged opposite the rough bearing surface relative to the filter and blocking an opening made through the housing.