Biological Material Comminuting Device Partition Wall
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Solution Overview
Problem
Existing comminuting devices for biological materials tend to deteriorate the material and produce non-homogeneous cellular grafts, leading to low cell leakage percentages due to tearing or laceration, rather than achieving precise and homogeneous cuts.
Innovation Solution
A comminuting device with fixed and movable cutting elements arranged above a partition wall, featuring calibrated holes and concentric arc-of-a-circle teeth, which cooperate to provide a precise, clean, and homogeneous cutting action, allowing for the production of cellular grafts with uniform shape and dimensions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a rotating element cooperates with a fixed pierced disc to comminute biological material, then the material is comminuted through tearing or laceration, but the material is deteriorated and non-homogeneous cellular grafts are produced
Solution Approach 1:
The device divides the comminuting chamber into an upper chamber for receiving biological material and a lower chamber for collecting comminuted material, separated by a partition wall with calibrated holes. This segmentation allows for controlled comminution in the upper chamber while collecting homogeneous grafts in the lower chamber, preventing deterioration and ensuring uniform cellular graft production.
Solution Approach 2:
The invention uses a rotor with cutting elements that rotate at controlled speeds (70-100 rpm) to change the mechanical action from high-speed tearing to precise cutting. The calibrated holes in the partition wall (200-400 μm diameter) control the size and homogeneity of comminuted material passing through, transforming the output parameter to achieve uniform cellular grafts without material deterioration.
2Reliability
If microholes with diameter D ranging between 70 and 80 microns are used in the comminuting grid, then cell leakage percentage is reduced, but manufacturing precision of homogeneous cellular grafts is compromised
Solution Approach 1:
The invention optimizes the calibrated holes diameter to 200-400 μm, which is larger than the conventional 70-80 μm microholes. This parameter change allows sufficient cell leakage (improving reliability) while the controlled cutting action and partition wall design maintain homogeneous graft production (improving manufacturing precision). The larger holes prevent clogging and allow better flow while maintaining graft uniformity through the cutting mechanism.
3Speed
If a rotor with cutting elements rotates at high speed to comminute biological material, then comminuting speed is improved, but material deterioration increases
Solution Approach 1:
The invention optimizes the rotation speed to a controlled range of 70-100 rpm, which is sufficient for effective comminution but low enough to prevent material deterioration. This parameter optimization allows the cutting elements to efficiently comminute biological material while maintaining cell vitality and preventing the harmful effects of excessive speed such as heat generation and mechanical damage.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves a statistically higher percentage of cell leakage and maintains cell vitality, enabling more efficient cellular preparations for research and medical applications by producing homogeneous cellular grafts.
Implementation Method 1
a rotor (27) housed in said outer body and provided in a surface facing said partition wall with a number of sectors (29) provided with concentric arc-of-a-circle teeth (29')
Data Source
AI summary
A comminuting device of biological material includes a casing that contains fixed cutting elements and movable cutting elements cooperating with each other to grind biological material, a collecting chamber for ground biological material, and a partition wall adjacent to the collecting chamber. The fixed and movable cutting elements are above the partition wall together with the biological material to be ground. The collecting chamber is below the partition wall. The fixed cutting elements are in the form of elongated corners that extend radially. The movable cutting elements are in the form of elongated corners that extend radially. The partition wall is provided with wall portions. Calibrated holes are provided for the passage of biological material ground by the fixed cutting elements and the movable cutting elements. The collecting chamber is in connection with the outside of the casing through at least a channel.