Biological Detection Chip Transistor Array for Rapid Viral Analysis
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Solution Overview
Problem
Conventional biological detection methods are complex, time-consuming, and require specialized equipment and expertise, making them unsuitable for rapid and sensitive detection of biological targets outside laboratory settings, particularly in regions with limited testing facilities.
Innovation Solution
A biological detection chip with a plurality of transistors arranged in an array, featuring a substrate layer, floating gate, and a biological detection layer with immobilized probes, allowing for parallel detection of biological targets through changes in gate voltage and drain current, enabling rapid and sensitive detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional biological detection methods (immunoassays, RT-PCR) are used, then detection accuracy can be maintained, but detection time increases significantly and operational complexity increases
Solution Approach 1:
The patent replaces complex mechanical/biological detection systems (immunoassays, RT-PCR) with an electronic field-effect transistor-based detection system. The biological probe-transistor structure directly converts biological binding events into electrical signal changes, eliminating the need for complex mechanical operations and lengthy processing steps while maintaining detection accuracy.
Solution Approach 2:
The patent changes the detection parameter from complex multi-step biological/chemical readouts to direct electrical parameter measurements (gate voltage, drain current). This parameter transformation enables rapid, real-time detection while preserving measurement precision through the sensitive electrical response of the transistor to biological binding events.
2Reliability
If conventional biological detection methods are used, then detection capability is achieved, but device complexity and operational difficulty increase
Solution Approach 1:
The patent extracts the essential detection function from complex conventional systems and isolates it into a single integrated transistor-based device. By removing unnecessary complex equipment and focusing on the core detection mechanism (electrical signal change upon biological binding), the system maintains reliability while dramatically reducing device complexity.
Solution Approach 2:
The patent creates a universal detection platform where a single transistor structure can detect various biological targets by simply changing the biological probe layer. This multi-functional design eliminates the need for different specialized equipment for different检测 tasks, reducing overall device complexity while maintaining broad detection capability.
3Adaptability or versatility
If conventional biological detection methods are used, then comprehensive detection can be performed, but ease of operation decreases
Solution Approach 1:
The patent creates a dynamic, easily reconfigurable detection system where the biological probe layer can be changed to detect different targets. The electronic measurement process is inherently simple and rapid, allowing operators to easily switch between different detection scenarios without complex procedural changes, thus improving ease of operation while maintaining versatility.
4Measurement precision
If conventional biological detection methods are used, then detection can be performed, but sensitivity and detection speed are reduced
Solution Approach 1:
The patent replaces slow, multi-step mechanical/biological detection processes with rapid electrical measurements. The field-effect transistor provides immediate electrical signal response upon biological binding, simultaneously achieving high sensitivity through signal amplification and high speed through direct electrical readout without intermediate steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The chip provides high sensitivity, rapid detection, and easy operation, with improved detection accuracy and stability, capable of detecting various biological targets, including viruses and cortisol, facilitating implementation in diverse industries.
Implementation Method 1
measuring a gate voltage and a drain current of the plurality of transistors
Data Source
AI summary
The present invention disclosed a biological detection chip and its application thereof. The biological detection chip includes a plurality of transistors in parallel. Each of the transistors includes a substrate layer, a floating gate, an extending metal connector, an extending gate, and a biological detection layer. The biological detection chip is combined with biological probes after the surface modification process for biological detection. Biological detection includes Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Porcine Epidemic Diarrhea Virus (PEDV), and Cortisol detection.