Biological Fluid Phototreatment with Multi-Wavelength Light Control
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Solution Overview
Problem
Existing systems for treating biological fluids, such as blood products, face challenges in efficiently reducing pathogen inactivation compounds after photochemical treatment while maintaining pathogen inactivation and minimizing damage to the fluids, with a need for improved monitoring and control of treatment parameters.
Innovation Solution
A treatment system with a first array of light sources emitting light at specific peak wavelengths, including ultraviolet A, B, and C spectra, and a control circuitry to adjust light parameters based on sensor feedback, ensuring uniform illumination and reduced variance in irradiance across the fluid surface.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If photochemical treatment is used to inactivate pathogens in biological fluids, then pathogen inactivation is achieved, but residual pathogen inactivation compounds remain in the treated fluid
Solution Approach 1:
The system extracts and removes residual pathogen inactivation compounds (such as amotosalen) and photoproducts from the treated biological fluid using a compound adsorption device (CAD) that selectively binds and removes these compounds through adsorption, thereby eliminating the harmful residual substances while preserving the inactivated pathogens
2Productivity
If higher intensity light is used to improve treatment efficiency, then pathogen inactivation is enhanced, but damage to the biological fluid increases
Solution Approach 1:
The system dynamically adjusts light treatment parameters including intensity, wavelength, and exposure duration based on real-time monitoring of treatment progress and fluid characteristics, allowing optimization of pathogen inactivation while minimizing damage to the biological fluid components
Solution Approach 2:
The system changes multiple treatment parameters simultaneously including light wavelength selection, irradiance intensity, treatment duration, and temperature control to achieve optimal balance between pathogen inactivation efficiency and preservation of biological fluid quality
3Reliability
If multiple light source channels with different wavelengths are used, then treatment effectiveness is improved, but device complexity increases
Solution Approach 1:
The light source array is segmented into multiple independent channels, each emitting at a specific wavelength optimized for different aspects of pathogen inactivation and compound removal, allowing selective activation of channels based on treatment requirements while maintaining manageable system complexity through modular design
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively reduces pathogen inactivation compounds and minimizes fluid damage by optimizing light treatment parameters, enhancing the quality and efficiency of biological fluid treatment.
Implementation Method 1
A first array of light sources may be positioned to illuminate the biological fluid in the treatment chamber. The first array of light sources may comprise one or more light source channels that illuminate the biological fluid with light of selected peak wavelengths.
Implementation Method 2
one or more light sensors configured to detect light in the treatment chamber
Implementation Method 3
The light sources emit light within a selected range of wavelengths that are effective to inactivate pathogens in the biological fluid, particularly by photochemical inactivation of pathogens.
Data Source
AI summary
Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.