Biological Patch Drainage Layout for Hematoma and Seroma Control
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Solution Overview
Problem
Existing biological prostheses face challenges in minimizing adverse events such as hematoma and seroma formation while ensuring effective functional reconstruction, particularly due to inadequate drainage systems and mechanical resistance issues.
Innovation Solution
A biological prosthesis with a drainage system featuring a regular body-centered hexagon layout of holes, 1.5 mm in diameter and 1.5 cm apart, optimized for efficient fluid drainage and mechanical strength, using bovine pericardium or swine derma after multiphasic decellularization, without surfactants, ensuring secure fastening and reduced cell sealing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a biological prosthesis is used for reconstructive surgery, then tissue growth and biocompatibility are improved, but drainage of hematomas and seromas is insufficient leading to adverse events
Solution Approach 1:
The biological prosthesis is designed with a porous structure containing multiple drainage channels that allow hematomas and seromas to be evacuated from the surgical site. The porous architecture enables fluid transport pathways while maintaining the biocompatible biological material structure, thus resolving the contradiction between tissue compatibility and drainage capability
Solution Approach 2:
The prosthesis is segmented into multiple functional zones with distributed drainage channels throughout its structure. This segmentation allows different regions of the prosthesis to independently manage fluid drainage, preventing localized hematoma and seroma accumulation while maintaining overall biocompatibility
2Object-generated harmful factors
If drainage holes are added to the prosthesis, then fluid drainage is improved, but mechanical resistance and structural strength are reduced
Solution Approach 1:
The prosthesis utilizes a controlled porous structure where drainage channels are integrated into the material architecture. This porous design enables fluid drainage functionality while the overall structural integrity is maintained through the engineered pore distribution and size, preventing excessive weakening of mechanical resistance
Solution Approach 2:
The prosthesis combines biological material with an integrated drainage system structure, creating a composite construct. The drainage channels are formed as part of the prosthesis architecture rather than separate components, allowing the system to achieve both drainage functionality and structural strength through the composite design
3Strength
If synthetic mesh is used for abdominal wall reconstruction, then mechanical strength is improved, but infection risk and tissue growth are worsened
Solution Approach 1:
The prosthesis changes the material parameter from synthetic to biological origin, fundamentally altering the interaction with host tissues. This parameter change reduces infection risk and improves tissue compatibility while the engineered structural architecture compensates for any reduction in raw mechanical strength through optimized load distribution
Solution Approach 2:
The porous structure with drainage channels in the biological prosthesis facilitates fluid evacuation and reduces localized fluid accumulation that could lead to infection. The porous architecture also allows for better tissue integration and drainage, addressing the infection risk issue while maintaining adequate mechanical support
Data Source
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AI summary
The present invention relates to an innovative biological prostheses, equipped with a drainage system, designed for all surgical applications where there is any risk of hematomas or seromas, which not only allows to minimize adverse events arising from its application, but allows also to Improve the effectiveness of the functional reconstruction.