Biological Polysaccharide Hydrogel with Aldehyde Side-Chain Crosslinking
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Solution Overview
Problem
Current vitreous substitutes used in vitrectomy surgeries suffer from short effective pressure-holding time, rapid degradation, and toxic side effects, necessitating improved biocompatibility and extended degradation time.
Innovation Solution
A biological polysaccharide hydrogel is formulated by cross-linking a polysaccharide derivative with an aldehyde group on a side chain with another polysaccharide derivative or a small molecule compound having primary amino groups, ensuring the main chain integrity and incorporating side-chain grafted structures to resist enzymatic degradation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If ring-opening oxidation is used to form hydrogel, then gelation is achieved, but molecular weight is significantly reduced and degradation time is shortened
Solution Approach 1:
The oxidation is segmented to occur only on side chains rather than the main chain. The patent uses controlled oxidation conditions to selectively oxidize side chain hydroxyl groups to aldehyde groups while preserving the integrity of the main chain, thus achieving gelation without significant molecular weight reduction
Solution Approach 2:
The oxidation reaction is localized to specific regions (side chains) of the polysaccharide structure. By controlling the oxidation to occur only on side chains with adjacent hydroxyl groups, the main chain remains intact and maintains its molecular weight, while still forming crosslinks for gelation
2Duration of action of moving object
If silicone oil is used as vitreous substitute, then pressure-holding time is extended, but toxic side effects and emulsification complications occur
Solution Approach 1:
The patent converts the biodegradability of polysaccharides, which was previously a drawback leading to short pressure-holding time, into a benefit by modifying the structure to resist degradation. The controlled oxidation and crosslinking create a hydrogel that degrades slowly over months, eliminating toxic accumulation while maintaining extended pressure support
Solution Approach 2:
The patent changes the chemical parameters of the polysaccharide by introducing aldehyde groups through controlled oxidation and forming crosslinks with amino compounds. This modifies the degradation rate from rapid to extended (months), achieving both biocompatibility and sustained pressure-holding time
3Object-affected harmful factors
If gas is used as vitreous substitute, then biocompatibility is good, but effective pressure-holding time is short
Solution Approach 1:
The patent creates a composite hydrogel system combining oxidized polysaccharide chains with amino-containing crosslinking agents. This composite structure provides both the biocompatibility of natural polysaccharides and the extended durability needed for sustained pressure support, overcoming the limitations of both gas and traditional silicone oil
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogel exhibits enhanced biodegradation resistance, leading to extended pressure-holding time and improved biocompatibility, reducing toxic side effects on eye tissues.
Implementation Method 1
cross-linking a polysaccharide derivative with an aldehyde group on a side chain with another polysaccharide derivative or a small molecule compound having primary amino groups
Implementation Method 2
the polysaccharide derivative with an aldehyde group on a side chain is formed by the reaction of an aqueous solution of a polysaccharide derivative having a grafted o-dihydroxyl group with an oxidizing agent
Implementation Method 3
incorporating side-chain grafted structures to resist enzymatic degradation
Data Source
AI summary
The present invention relates to a biological polysaccharide hydrogel, a preparation method therefor and an application thereof. The biological polysaccharide hydrogel of the present invention is formed by means of the mixing and reaction of two solutions; the first solution is a polysaccharide derivative solution having an aldehyde on a side chain; the second solution is a polysaccharide derivative solution having a primary amine on a main chain or a side chain, or a small molecule compound solution having two or more primary amines. The preparation method of the present invention comprises preparing the first solution and the second solution, and then mixing the first solution and the second solution to form a transparent biological polysaccharide hydrogel. The biological polysaccharide hydrogel of the present invention can be applied as a vitreous substitute.