Packaging For Biological Samples

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Solution Overview

Problem

Existing packaging solutions for biological samples, particularly tumor tissues, fail to provide secure, temperature-controlled transportation that prevents degradation and leakage while ensuring traceability and tamper evidence.

Innovation Solution

A packaging and transporting device comprising an insert with cut outs for securing strips, temperature sensors, and securing elements, a transport bag with absorbent sheets, and a cooling engine to maintain specific temperature ranges, along with labeling and sealing mechanisms to ensure secure and traceable transport.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing packaging solutions are used for biological samples, then the packaging structure is simple, but the samples are not securely protected against degradation, leakage, and tampering

Engineering Contradiction:
Improvesample integrityVSAvoidpackaging structure
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The packaging system is divided into multiple functional components: an inner container for the biological sample, an outer container for protection, insulation material for temperature control, and various sealing mechanisms. This segmentation allows each component to perform its specific function optimally while collectively providing comprehensive protection for the sample.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The packaging employs a nested structure where the inner container holding the biological sample is placed within the outer container. The inner container is surrounded by insulation material, and the entire assembly is sealed within the outer container. This nested arrangement maximizes protection while organizing components efficiently.

Inventive Principle:
Principle #7Nested doll (Nesting)

2Reliability

If temperature control is not implemented, then the packaging is simpler, but biological samples degrade during transportation

Engineering Contradiction:
Improvesample stabilityVSAvoidtemperature control system
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

Insulation material is placed between the inner and outer containers before transportation to prevent temperature fluctuations. This pre-established thermal barrier protects the temperature-sensitive biological sample from external environmental changes during transit without requiring active temperature control systems.

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

3Reliability

If securing mechanisms are not used, then the packaging is easier to open, but tampering cannot be detected and samples can be accessed unauthorized

Engineering Contradiction:
Improvetamper evidenceVSAvoidopening process
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

Tamper-evident seals or indicators are used that change color or show visible signs when the packaging has been opened or compromised. This allows quick visual verification of sample integrity without requiring complex inspection procedures, balancing security with ease of verification.

Inventive Principle:
Principle #32Color changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device effectively maintains biological samples within a predetermined temperature range, prevents leakage, and provides tamper evidence, ensuring the integrity and safety of the samples during transportation.

Implementation Method 1

a cooling engine to maintain a predetermined temperature range

Methodology Applied
Scientific EffectThermal control:

Implementation Method 2

The transport bag includes an absorbent sheet configured to absorb leakage of the sample container

Methodology Applied
Scientific EffectAbsorption: Absorption (physical)

Data Source

PatentUS20250380932A1Packaging For Biological Samples
Publication Date: 2025.12.18 IOVANCE BIOTHERAPEUTICS INC
  • US20250380932A1 patent drawing
  • US20250380932A1 patent drawing
  • US20250380932A1 patent drawing

AI summary

A packaging and transporting device for a biological sample including an insert, a securing strip, a securing element, a temperature sensor, a plurality of labels, a shipping pouch sized and shaped to receive a shipping document, and a transport bag configured to receive a sample container. The insert comprises a plurality of cutouts sized and shaped to receive the securing strip, the securing element, and the temperature sensor. At least one of the plurality of labels includes patient information.