Automated Biological Sample Processor with Independent Substrate Holders
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Solution Overview
Problem
Current batch sample processors in biological sample analysis are inefficient, leading to delayed patient results, inconsistent processing, and increased labor costs due to their inability to handle varying processing times and sample types effectively.
Innovation Solution
An automated biological sample processing apparatus with independently movable substrate holders and a movable sample processor that allows for simultaneous processing of multiple samples, enabling continuous access and reagent replenishment without interrupting ongoing processes, and allowing for individual samples to be added or retrieved without halting the system.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If batch sample processors are used to process multiple samples simultaneously, then productivity is improved, but all samples must wait for the longest processing time causing loss of time for faster samples
Solution Approach 1:
The batch processor is segmented into multiple independent processing modules, each capable of handling individual samples separately. This allows samples with different processing requirements to be handled in parallel without mutual interference, eliminating the waiting time caused by the longest processing sample while maintaining high throughput.
Solution Approach 2:
The system dynamically assigns samples to different processing modules based on their specific processing requirements and timelines. Samples can be routed to appropriate modules that can complete their processing fastest, optimizing the overall throughput while minimizing waiting time for each sample.
2Ease of operation
If manual staining processes are performed by multiple different persons, then ease of operation is maintained, but manufacturing precision deteriorates due to inconsistent staining
Solution Approach 1:
The automated processing modules perform staining operations autonomously without human intervention. Pre-programmed protocols ensure that each sample receives identical processing conditions, eliminating variability introduced by different operators while maintaining operational flexibility through programmable parameters.
Solution Approach 2:
The system allows staining parameters such as reagent concentration, temperature, and timing to be precisely controlled and adjusted through programming. This enables consistent reproduction of staining conditions across all samples while allowing flexibility to optimize parameters for different sample types.
3Productivity
If batch processors are used to improve productivity, then device complexity increases, but adaptability deteriorates due to inability to handle varying processing times and sample types
Solution Approach 1:
Each processing module is designed with universal capabilities to handle multiple sample types and processing protocols. The modules can be programmatically configured to accommodate different staining methods, reagent combinations, and processing timelines, providing both high productivity and broad adaptability.
Solution Approach 2:
The system dynamically reconfigures processing parameters and sample routing based on the specific requirements of each sample type. This allows the processor to adapt to varying processing times and methodologies while maintaining efficient throughput through automated schedule optimization.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enhances workflow efficiency by enabling continuous processing, reducing turn-around time, and improving consistency in sample analysis, allowing for flexible handling of varying sample needs and minimizing labor costs.
Implementation Method 1
each substrate support unit includes independent thermal control units that permit independent temperature programming of the substrate support units and the substrates placed thereon
Implementation Method 2
Each substrate support unit also includes a non-contact temperature sensor that is positioned to measure a temperature of the substrate or sample
Data Source
AI summary
An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.