Automated Cartridge Reagent Loading for Biological Sample Processing
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Solution Overview
Problem
Current biological sample analysis techniques face limitations such as wasted reagents, lack of flexibility in test menus, and high costs, along with low throughput.
Innovation Solution
A method involving an automated robotic system that retrieves information from a sample vessel's storage unit to select and load appropriate reagents into cartridges for a sample processing device, optimizing reagent usage and test selection based on the information, and using robots to assemble and transport cartridges to processing devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of substance
If current biological sample analysis techniques are used, then sample processing can be performed, but reagent waste occurs and costs increase
Solution Approach 1:
The system performs preliminary actions by pre-configuring cartridges with specific reagents and components based on the test menu selected for each sample. The robotic system loads only the necessary reagents into cartridges before sample analysis, preventing reagent waste by avoiding unnecessary loading and disposal operations. This preliminary configuration ensures that reagents are used efficiently and only when needed for specific tests.
Solution Approach 2:
The system changes parameters by dynamically selecting and configuring different cartridge types based on the specific test requirements. By varying the cartridge configuration parameters (which reagents are included, which test modules are activated) according to the selected test menu, the system optimizes reagent usage for each specific analysis task, reducing waste while maintaining analytical capability.
2Adaptability or versatility
If current biological sample analysis techniques are used, then sample processing can be performed, but flexibility in test menu is limited
Solution Approach 1:
The system segments the test menu into multiple selectable test types, each corresponding to specific cartridge configurations. By dividing the overall testing capability into discrete, selectable modules (different test menus), the system provides flexibility for users to choose only the tests needed for each sample, while the robotic system automatically configures the appropriate cartridge for each selected test combination.
Solution Approach 2:
The robotic sample processing system provides universal functionality by being capable of performing multiple different test types through a single integrated platform. The system can be programmed to handle various test menus and automatically configure cartridges accordingly, making one system versatile enough to replace multiple specialized systems while maintaining ease of operation through automated configuration.
3Productivity
If current biological sample analysis techniques are used, then sample processing can be performed, but throughput is low and cost is high
Solution Approach 1:
The robotic sample processing system enables continuous useful action by automating the entire cartridge configuration and sample analysis workflow. Once programmed, the system continuously processes samples through automated reagent loading, cartridge assembly, and analysis execution without manual intervention between steps. This continuous automated operation increases throughput by eliminating idle time and manual handling delays.
Solution Approach 2:
The system performs preliminary actions by pre-configuring cartridges with all necessary reagents and components before sample analysis begins. This preliminary setup eliminates the need for manual reagent addition during the analysis process, allowing samples to be processed continuously through the automated system without interruption for manual preparation steps, thereby increasing overall throughput.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces reagent waste, enhances flexibility in testing, and increases throughput by optimizing reagent usage and streamlining the sample processing workflow.
Implementation Method 1
using robots to assemble and transport cartridges to processing devices
Implementation Method 2
loading appropriate reagents into cartridges for a sample processing device
Data Source
AI summary
Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge front at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge.