Biological Stomach Wrapping to Limit Post-Bariatric Dilation
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Solution Overview
Problem
Current bariatric surgeries like sleeve gastrectomy face challenges in maintaining long-term weight loss due to gastric dilation, with existing methods causing complications such as gastric wall erosion and weight regain, and there is a need for a method that effectively restricts gastric expansion without affecting gastric wall peristalsis.
Innovation Solution
The use of a decellularized matrix or absorbable biological material, such as an artificial extracellular matrix or high molecule compound, to wrap around the stomach after gastric volume reduction surgery, providing reinforcement and maintaining gastric volume through mechanical support and eventual tissue remolding into an elastic band.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If sleeve gastrectomy is performed to reduce gastric volume, then weight loss effect is improved, but gastric dilation occurs leading to weight regain
Solution Approach 1:
The biological material is implanted into the gastric wall during the initial sleeve gastrectomy procedure, forming a reinforced structure that prevents future dilation. This preliminary reinforcement action addresses the contradiction by preparing the gastric wall in advance to maintain its reduced volume shape, preventing the weight regain that would otherwise occur due to gastric dilation.
2Quantity of substance
If gastric banding surgery is used to limit gastric volume, then weight loss is achieved, but gastric wall erosion and chronic gastric perforation occur
Solution Approach 1:
The biological material serves as an intermediary layer between the gastric wall and any external constriction forces. This intermediary structure distributes mechanical stresses evenly across the gastric wall, preventing the localized pressure points that cause erosion and perforation in traditional banding procedures, while still achieving volume restriction.
Solution Approach 2:
The invention changes the physical parameters of the gastric wall by incorporating a biological material that modifies its mechanical properties. The material provides structural support and distributes forces, changing the stress distribution parameters across the gastric wall, thereby preventing erosion and perforation while maintaining volume restriction.
3Quantity of substance
If adjustable gastric band is used to limit gastric volume, then structure can be recovered after removing the band, but gastric obstruction and patient death may occur
Solution Approach 1:
The biological material is designed to be bioabsorbable, meaning it gradually degrades and is absorbed by the body over time. This self-service property allows the material to provide structural support when needed, then naturally disappear after serving its purpose, eliminating the need for removal surgery and avoiding the harmful effects of permanent foreign bodies that could cause obstruction.
4Reliability
If weight-loss drugs such as orlistat and phentermine are used for long-term weight maintenance, then weight regain is prevented, but obvious side effects occur
Solution Approach 1:
The invention replaces the chemical/pharmacological approach of weight-loss drugs with a mechanical/structural approach. By implanting a biological material that physically maintains gastric volume restriction, the need for long-term drug therapy is eliminated, providing reliable weight maintenance without the harmful side effects associated with prolonged medication use.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biological material effectively limits gastric expansion, maintaining gastric volume and preventing weight regain while avoiding gastric wall stiffness and associated discomforts, ensuring long-term weight maintenance without compromising gastric function.
Implementation Method 1
providing reinforcement and maintaining gastric volume through mechanical support
Implementation Method 2
eventual tissue remolding into an elastic band
Data Source
AI summary
Provided is a use of a biological material in preparing a product for limiting gastric volume. The biological material is selected from a decellularized matrix, an artificial extracellular matrix and a high molecule compound. The wrapping of a remaining stomach after gastric volume reduction surgery by the biological material can effectively reduce the expansion of the gastric volume after the surgery for a long time. The gastric volume of the remaining stomach can be effectively maintained, avoiding the occurrence of weight regain caused by the expansion of the remaining stomach. The decellularized matrix and a biological material remolded tissue have the viscoelasticity equivalent to or close to natural tissue, avoiding gastric wall stiffness, and thus not affecting gastric wall peristalsis.