BioMAP Neural Synchrony Detection for Learning Disability Diagnosis

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Solution Overview

Problem

Current methods for diagnosing central auditory processing disorders and associated learning disabilities are subjective and lack a consistent, reliable physiological indicator, failing to establish a clear connection between auditory brainstem response results and learning disabilities.

Innovation Solution

A system and method utilizing a biological marker (BioMAP) that reflects preconscious aggregate neural activity in the auditory brainstem pathway, providing an objective evaluation through electrophysiological acquisition and comparison to a database of normative responses to identify clinically relevant neural synchrony and predict hearing and learning disabilities.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional ABR testing is used to assess auditory brainstem response, then physiological indication is provided, but no connection has been established between test results and learning disabilities

Engineering Contradiction:
Improveconnection between ABR results and learning disabilitiesVSAvoidinformation about learning disability connection
Core Design Contradiction:
ReliabilityVSLoss of information

Solution Approach 1:

The patent introduces an intermediary analysis layer that connects ABR waveform characteristics to learning disability diagnostics. By analyzing specific waveform features (latency, amplitude, slope) and comparing them against normative data, the system creates a bridge between the physiological ABR measurements and learning disability assessments, enabling the previously unconnected information to speak to each other.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces subjective perceptual and audiological testing with objective electrophysiological measurement and automated analysis. The mechanical/system replacement involves using computer-based automated waveform analysis and pattern recognition algorithms to substitute for traditional human-based diagnostic methods, thereby establishing more reliable objective connections to learning disabilities.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If subjective perceptual and audiological tests are used for CAP evaluation, then diagnostic information is obtained, but the methods lack consistency and reliability

Engineering Contradiction:
Improveconsistency and reliability of diagnosisVSAvoidprecision of diagnostic measurement
Core Design Contradiction:
ReliabilityVSMeasurement precision

Solution Approach 1:

The patent replaces subjective human-based diagnostic methods with objective automated electrophysiological measurement and computer analysis. By using standardized electrical signal recording and automated waveform analysis algorithms, the system eliminates variability in human interpretation and provides consistent, precise measurements that can be reliably compared across different patients and time points.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent transforms the diagnostic approach by changing from subjective perceptual parameters to objective electrophysiological parameters. By measuring specific waveform characteristics (latency in milliseconds, amplitude in microvolts, slope rates) and comparing them against established normative ranges, the system achieves precise and reliable diagnostic criteria that are independent of observer judgment.

Inventive Principle:
Principle #35Parameter changes

3Adaptability or versatility

If multiple factors are considered in diagnosing learning disabilities, then comprehensive evaluation is achieved, but the diagnostic method becomes complex and variable

Engineering Contradiction:
Improvecomprehensive evaluation capabilityVSAvoidcomplexity of diagnostic method
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent segments the complex diagnostic evaluation into distinct, manageable components: (1) objective ABR waveform acquisition, (2) automated waveform parameter extraction, (3) comparison against normative data, and (4) diagnostic interpretation. This segmentation allows the comprehensive evaluation to be broken down into standardized steps that reduce overall complexity while maintaining versatility across different patient populations.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent creates a standardized template or copy of the diagnostic process that can be consistently applied to different patients. By using standardized waveform analysis protocols and pre-established normative reference data, the system provides a replicable diagnostic framework that maintains comprehensive evaluation capabilities while reducing variability and complexity through standardization.

Inventive Principle:
Principle #26Copying

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables early detection of childhood learning disabilities and aids in the selection of hearing corrective appliances and auditory training regimens by offering a consistent and reliable objective assessment of central auditory processing disorders.

Implementation Method 1

Transient acoustic events induce a pattern of voltage fluctuations in the brainstem resulting in a familiar waveform that yields information about brainstem nuclei along the ascending central auditory pathway

Methodology Applied
Scientific EffectElectrophysiological response:

Data Source

PatentUS8712514B2Neurophysiological central auditory processing evaluation system and method
Publication Date: 2014.04.29 NORTHWESTERN UNIV
  • US8712514B2 patent drawing
  • US8712514B2 patent drawing
  • US8712514B2 patent drawing

AI summary

A system and method of central auditory processing testing and evaluation provides for identifying clinically relevant neural synchrony in the auditory brainstem pathway. The system or method finds use as a tool to evaluate auditory processing disorders, and hence, potential auditory system and/or learning disabilities. The system or method may further find use in the selection and fitting of hearing corrective appliances such as hearing aid or cochlear implant devices and/or in the selection and implementation of auditory training regimens.