Biomarker Detection Device with Antibody-Bound Membrane
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Solution Overview
Problem
Current methods for detecting biomarkers in fluid samples are laborious and time-consuming, requiring extensive analysis in laboratory settings, which hinders early disease detection and monitoring.
Innovation Solution
A device comprising an upper container with a membrane that allows selective transmission of fluid samples, enabling point-of-care detection of biomarkers by binding antibodies to the membrane, allowing for rapid identification of biomarkers in bodily fluids without the need for laboratory analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional laboratory analysis methods are used to detect biomarkers, then measurement precision can be achieved, but loss of time and device complexity increase significantly
Solution Approach 1:
The invention extracts the detection function from complex laboratory settings and implements it in a simplified point-of-care device. The membrane with bound antibodies is removed from laboratory processing and placed in a portable container system that can be used at the collection site, enabling rapid detection without sacrificing measurement precision.
Solution Approach 2:
The membrane acts as an intermediary element that binds antibodies and facilitates biomarker detection. This membrane intermediary enables the transition from complex laboratory analysis to simple point-of-care testing by capturing biomarkers directly in the fluid sample and making them detectable without extensive laboratory processing.
2Measurement precision
If traditional laboratory analysis methods are used to detect biomarkers, then measurement precision can be achieved, but device complexity increases
Solution Approach 1:
The invention extracts the essential detection function from complex laboratory equipment and implements it in a simple container-membrane system. By removing unnecessary complexity and retaining only the critical detection elements (membrane with antibodies), the device achieves laboratory-grade precision with minimal complexity.
Solution Approach 2:
The invention applies local quality by concentrating the detection function in the membrane region rather than distributing complexity throughout a laboratory system. The membrane with specifically bound antibodies provides localized, high-precision detection capability within the simple container structure.
3Speed
If membrane transmission is used for rapid detection, then speed improves, but measurement precision may be compromised
Solution Approach 1:
The invention applies preliminary action by pre-binding antibodies to the membrane before sample application. This preliminary preparation ensures that when the fluid sample rapidly passes through the membrane, the biomarkers are immediately captured and detected with high precision, eliminating the need for subsequent complex processing steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables quick detection of low or trace quantities of biomarkers, providing rapid prognosis or diagnosis at the collection site, reducing the need for laboratory testing and allowing for point-of-care diagnostics, multiplex testing, and repeated use, while also applicable for environmental contaminant detection.
Implementation Method 1
a membrane configured to allow transmission of a portion of the fluid sample through the membrane
Data Source
AI summary
The disclosure is directed to a device that includes an upper container configured to receive a fluid sample collected from a mammal into a first opening, the first opening opposite a second opening and a membrane covering at least a portion of the second opening, the membrane configured to allow transmission of a portion of the fluid sample through the membrane.