Biomarker Visualization Interface for Simultaneous Multi-Aspect Analysis
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Solution Overview
Problem
Current methods for visualizing biomarker expression in biological specimens are limited in their ability to efficiently display and analyze multiple biomarkers and morphological features simultaneously, requiring cumbersome processes and lacking in user-friendly interfaces for rapid and objective diagnosis.
Innovation Solution
A computer-implemented method and system for displaying biomarker expression levels in a biological specimen, utilizing a split screen display and digital prism interface that allows for simultaneous viewing of different aspects of a field of view, with image sub-panels showing biomarker expressions and morphological features, and enabling seamless alignment and zooming, using tiled multi-resolution data structures for efficient data access.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of information
If multiple biomarkers and morphological features are displayed simultaneously using traditional methods, then comprehensive analysis is improved, but system complexity and ease of operation deteriorate due to cumbersome processes and lack of user-friendly interfaces
Solution Approach 1:
The display interface is segmented into multiple panes, each showing different biomarkers or morphological features. This allows comprehensive information to be organized into manageable sections, improving both completeness of analysis and ease of operation by presenting data in a structured, navigable format rather than overwhelming the user with all data at once.
Solution Approach 2:
The system transitions from traditional two-dimensional static displays to a multi-pane virtual slide interface that adds temporal and spatial dimensions. Users can navigate through multiple biomarker expressions and morphological features across different panes and time points, enabling comprehensive analysis while maintaining user-friendly control through standardized navigation interfaces.
2Productivity
If traditional visualization methods are used for biomarker expression, then simplicity is maintained, but productivity and diagnostic efficiency deteriorate due to inability to rapidly compare multiple biomarkers
Solution Approach 1:
The virtual slide interface serves multiple functions simultaneously: displaying multiple biomarkers, showing morphological features, enabling comparison across time points, and providing navigation controls. This multi-functional design improves diagnostic efficiency by consolidating what would otherwise require multiple separate tools or processes into a single unified interface.
Solution Approach 2:
The system creates virtual copies of tissue sections that can be displayed across multiple panes simultaneously. These virtual slides can be reproduced, navigated, and compared without requiring physical manipulation of multiple slide sections, thereby improving productivity while managing complexity through digital replication rather than physical handling.
3Measurement precision
If extensive data is loaded for comprehensive biomarker analysis, then measurement precision is improved, but loss of time increases due to extensive data loading requirements
Solution Approach 1:
The system performs preliminary actions by pre-processing and organizing biomarker data into virtual slide formats before user interaction. Multiple biomarker expressions and morphological features are pre-loaded and structured in the virtual slide interface, allowing users to immediately begin analysis without waiting for data loading during the diagnostic process, thereby reducing time loss while maintaining measurement precision.
Data Source
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AI summary
Embodiments provide a user interface including an image panel for displaying a field of view corresponding to an image, or a portion of an image, of a biological specimen, and a biomarker panel for displaying thumbnail images for simultaneously viewing different aspects of a region within the field of view. Upon selection or update of the selected region of the field of view, the thumbnail images may be accordingly updated automatically to display the newly selected region. The image panel may include an interest region selection component for delineating a region within the field of view. The interest region selection component may be overlaid over a portion of the field of view displayed in the image panel, and may be used by a user to select or update the region within the field of view displayed in the biomarker panel. Images of interest may be saved to an electronic record.