Biomedical Detection Chip for Parallel Drug Concentration Testing
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Solution Overview
Problem
Existing drug testing for cancer treatment is time-consuming and costly due to differences in patient responses, requiring extensive testing on various drug concentrations, which complicates drug design and financial burden.
Innovation Solution
A biomedical detection chip with a detection module that includes a distribution component for Gaussian distribution of stromal cells, flow channels for varying concentrations, and electrode modules for precise cell arrangement, allowing simultaneous testing of drug effects on cancer cells under different conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drug testing methods are used to test effects of drugs on cancer cells under different conditions, then comprehensive drug testing can be performed, but the testing time period becomes extremely long and costly
Solution Approach 1:
The detection chip divides the detection substrate into multiple detection regions, each containing flow channel units with different concentrations of stromal cells. This segmentation allows simultaneous testing of multiple drug concentrations on cancer cells in parallel, dramatically reducing the overall testing time while maintaining comprehensive coverage of different treatment conditions
Solution Approach 2:
The patent transitions from conventional single-condition sequential testing to multi-condition parallel testing by adding the dimension of spatial distribution. The Gaussian distribution structure creates a gradient of stromal cell concentrations across the substrate, enabling simultaneous evaluation of multiple treatment scenarios in a single experiment
2Measurement precision
If massive testing doses are used to account for individual patient differences, then accurate drug effect prediction is achieved, but the financial burden on patients increases
Solution Approach 1:
The detection chip creates local variations in stromal cell concentrations across different detection regions. Each region provides a specific microenvironment with controlled cell density, allowing the system to capture patient-specific response characteristics without requiring massive testing doses. The local quality of each detection region enables precise prediction of individual patient responses
Solution Approach 2:
The patent changes the parameter of stromal cell concentration to create different detection environments. By controlling the concentration of stromal cells in each flow channel unit, the system can simulate various patient conditions and drug responses, achieving accurate prediction with minimal testing material
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid and efficient testing of multiple drug concentrations on cancer cells, reducing testing time and cost by simulating varied cellular environments for precise drug evaluation.
Implementation Method 1
The distribution component is configured for allowing a liquid that enters from the receiving opening to be Gaussian distributed and to flow out from the outlets
Data Source
AI summary
A biomedical detection chip includes a detection module including a detection substrate, an input distribution unit, and flow channel units. The input distribution unit has a distribution component disposed in the detection substrate that has a receiving opening and outlets, and allowing a liquid that enters from the receiving opening to be Gaussian distributed and flow out from the outlets. The flow channel units respectively communicate with the outlets. Each of the flow channel units has a first flow channel part and a second flow channel part. The first flow channel part includes a first flow channel and a first chamber located in the detection substrate. The second flow channel part includes a second flow channel and a second chamber located in the detection substrate. Through the input distribution unit cooperating with the flow channel units, simultaneously testing effects of drugs on different concentrations of a targeted cell is achieved.