Biomedical Image Tile Selection for Efficient Classification

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Solution Overview

Problem

Computer vision algorithms for biomedical image classification are resource-intensive and time-consuming due to the large resolution and size of biomedical images, and existing methods struggle to effectively utilize large datasets for training high-capacity models.

Innovation Solution

A method involving an image classifier that generates tiles from biomedical images, establishes an inference system to score tiles for features indicative of specific conditions, and modifies the system based on error metrics to improve classification accuracy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If computer vision algorithms are applied to biomedical images with large resolution and size, then classification accuracy can be improved, but computational resources and time consumption increase significantly

Engineering Contradiction:
Improveclassification accuracyVSAvoidtime consumption
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The biomedical image is divided into multiple smaller tiles, allowing the classification algorithm to process each tile independently and in parallel. This segmentation reduces the computational burden on each processing unit while maintaining the ability to achieve accurate classification through aggregation of tile-level predictions.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Instead of processing all tiles uniformly, the system applies selective processing by identifying and focusing computational resources on tiles that are most likely to contain relevant features based on preliminary scoring, thereby reducing overall processing time while maintaining classification accuracy.

Inventive Principle:
Principle #16Partial or excessive action

2Reliability

If high-capacity models are trained on large datasets, then model performance and generalization improve, but computational resources and training time increase

Engineering Contradiction:
Improvemodel performanceVSAvoidcomputational resources
Core Design Contradiction:
ReliabilityVSUse of energy by moving object

Solution Approach 1:

The training process is segmented into multiple stages: first training on tile-level data to learn local features, then progressively training on aggregated image-level data. This staged approach allows the model to efficiently learn from large datasets without requiring excessive computational resources at any single training stage.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The system performs preliminary processing and feature extraction on tiles before the main training phase, preorganizing the large dataset into structured tile representations that can be more efficiently processed during model training, thereby reducing the computational burden during the actual training process.

Inventive Principle:
Principle #10Preliminary action

3Measurement precision

If all tiles in biomedical images are processed to ensure accurate classification, then classification accuracy improves, but processing time and computational load increase

Engineering Contradiction:
Improveclassification accuracyVSAvoidprocessing efficiency
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

Different processing strategies are applied to different regions of the image based on their likelihood of containing relevant features. Tiles with higher scores receive more thorough processing while low-scoring tiles receive minimal processing, optimizing the balance between accuracy and efficiency.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The system uses feedback from preliminary tile scoring to dynamically adjust processing depth and resource allocation. Tiles that show promise based on initial scoring receive additional processing passes, while tiles that clearly lack relevant features are quickly discarded, creating an adaptive processing pipeline that optimizes accuracy versus efficiency.

Inventive Principle:
Principle #23Feedback

Data Source

PatentUS12347569B2Systems and methods for multiple instance learning for classification and localization in biomedical imaging
Publication Date: 2025.07.01 MEMORIAL SLOAN KETTERING CANCER CENT
  • US12347569B2 patent drawing
  • US12347569B2 patent drawing
  • US12347569B2 patent drawing

AI summary

The present disclosure is directed to systems and methods for classifying biomedical images. A feature classifier may generate a plurality of tiles from a biomedical image. Each tile may correspond to a portion of the biomedical image. The feature classifier may select a subset of tiles from the plurality of tiles by applying an inference model. The subset of tiles may have highest scores. Each score may indicate a likelihood that the corresponding tile includes a feature indicative of the presence of the condition. The feature classifier may determine a classification result for the biomedical image by applying an aggregation model. The classification result may indicate whether the biomedical includes the presence or lack of the condition.