Biomedical Object Segmentation via Automated Image Annotation

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Solution Overview

Problem

Current methods for detecting biomedical objects within biological samples are labor-intensive, prone to human biases, and result in inconsistent outcomes, making them difficult to automate effectively.

Innovation Solution

A system and method for biomedical object segmentation utilizing processors, memory modules, and machine-readable instructions that analyze image data to automatically recognize and annotate biomedical objects, including a training server for generating and storing identifiable characteristics of these objects for consistent identification.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If automated systems are used for biomedical object detection, then productivity and consistency are improved, but the system complexity increases

Engineering Contradiction:
Improvedetection speedVSAvoidsystem complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent replaces manual visual inspection by trained professionals with an automated computer-based system that uses image processing and machine learning algorithms to detect and annotate biomedical objects. This substitution of mechanical/manual processes with automated computational processes directly improves productivity while managing system complexity through software-based solutions.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system creates a digital representation (copy) of the biological sample through image capture, then performs automated analysis on this copy. The trained model generates annotated copies of images with detected objects marked, allowing rapid reproduction of detection results without repeatedly examining original samples, thereby improving productivity.

Inventive Principle:
Principle #26Copying

2Measurement precision

If trained professionals perform visual detection, then detection accuracy is maintained, but loss of time increases

Engineering Contradiction:
Improvedetection accuracyVSAvoiddetection time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The system performs preliminary training of detection models using annotated images from trained professionals. This preliminary action creates a trained model that encapsulates expert knowledge, allowing the automated system to achieve comparable detection accuracy without requiring professionals to perform each detection task manually, thus reducing time loss while maintaining precision.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system uses feedback from user corrections and validations to continuously improve the trained model. By incorporating feedback loops where professional annotations refine the automated detection algorithm, the system maintains high detection accuracy while progressively reducing the time required for analysis.

Inventive Principle:
Principle #23Feedback

3Adaptability or versatility

If manual annotation is used, then flexibility in handling diverse objects is maintained, but productivity decreases

Engineering Contradiction:
Improvehandling flexibilityVSAvoidannotation speed
Core Design Contradiction:
Adaptability or versatilityVSProductivity

Solution Approach 1:

The system employs dynamic machine learning models that can adapt to different types of biomedical objects and imaging conditions. The trained model can be retrained and adjusted to handle diverse object types, providing flexibility comparable to manual annotation while achieving automated processing speeds, thus resolving the contradiction between adaptability and productivity.

Inventive Principle:
Principle #15Dynamics

Data Source

PatentUS11423536B2Systems and methods for biomedical object segmentation
Publication Date: 2022.08.23 ADVANCED SOLUTIONS LIFE SCIENCES LLC
  • US11423536B2 patent drawing
  • US11423536B2 patent drawing
  • US11423536B2 patent drawing

AI summary

In one embodiment, a system for biomedical object segmentation includes one or more processors; one or more memory modules communicatively coupled to the one or more processors, and machine readable instructions stored on the one or more memory modules. The machine readable instructions cause the system to perform the following when executed by the one or more processors: receive image data of one or more biological constructs; analyze the image data to generate processed image data via a data analytics module to recognize biomedical objects; and automatically annotate the processed image data to indicate a location of one or more biological objects within the one or more biological constructs.