Biomolecular Image Sensor for Direct Low-Concentration Detection
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Solution Overview
Problem
Traditional biomolecule detection methods require large and expensive equipment, complex processes, and additional image capture systems, limiting their suitability for point-of-care testing and reducing sensitivity, especially for low-concentration biomolecules.
Innovation Solution
A biomolecule image sensor with detection molecules on a light receiving surface, integrated photoelectric conversion elements, and readout circuits, allowing direct detection and quantification of biomolecules without additional equipment, enhanced by island structures and light blocking layers to improve sensitivity and reduce interference.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional biochemical tests use microscopes and additional photo equipment for detection, then detection capability is achieved, but device complexity and cost increase
Solution Approach 1:
The patent merges the biochemical detection function and the image capture function into a single integrated sensor device. The pixel element array directly detects luminescent signals from biomolecules without requiring separate microscopes or photo equipment, thereby reducing device complexity while maintaining detection capability.
Solution Approach 2:
The sensor device performs multiple functions: it serves as both the biochemical reaction substrate (through the bonding layer with detection molecules) and the imaging detection system (through the pixel element array). This multi-functionality eliminates the need for additional specialized equipment.
2Measurement precision
If traditional ELISA uses ELISA reader to detect absorbance, then quantification is achieved, but device complexity and cost increase
Solution Approach 1:
The patent combines the quantification function with the imaging sensor. The pixel element array directly captures luminescent signals and generates electrical signals for quantification, eliminating the need for separate ELISA readers while achieving accurate biomolecule concentration measurement.
3Measurement precision
If detection molecules are disposed on light receiving surface, then sensitivity for low-concentration biomolecules is improved, but manufacturing complexity increases
Solution Approach 1:
The detection molecules are pre-disposed on the light receiving surface of the pixel elements during the manufacturing process. The bonding layer is formed with detection molecules attached before the actual biochemical detection, allowing the sensor to be ready for immediate use with high sensitivity without requiring additional post-processing steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables real-time, sensitive detection of biomolecules with improved sensitivity, even at low concentrations, by directly capturing chemiluminescent or fluorescent signals from each unit pixel, reducing the need for large equipment and complex processes.
Implementation Method 1
each of the plurality of unit pixels comprises at least one photoelectric conversion element, the photoelectric conversion element receives an incident light to generate electrons
Data Source
AI summary
The present invention provides a biomolecule image sensor in which detection molecules are deposed on a light receiving surface of an image sensing element, and method thereof for detecting biomolecule.