Biomolecule Corona Sensor Array for Broad Cancer Detection
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Solution Overview
Problem
Current methods for early detection of diseases, particularly cancers, lack sensitivity and specificity, with no broadly relevant platform for identifying cancers at various stages and no clinically validated biomarkers for many types, leading to late detection and low survival rates.
Innovation Solution
A sensor array comprising a plurality of sensor elements with distinct physicochemical properties that bind biomolecules to form unique biomolecule corona signatures, allowing for the generation of a biomolecule fingerprint for disease diagnosis and prognosis, capable of detecting subtle changes in biomolecular compositions before symptom onset.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If molecular blood analysis for biomarkers is used for early detection, then detection capability is improved for some cancers, but no specific biomarkers are available for early detection of the majority of cancers including lung cancer
Solution Approach 1:
The sensor array uses a universal detection platform with multiple sensor elements that can detect various biomolecules from different cancer types through their distinct biomolecule corona signatures, eliminating the need for cancer-specific biomarkers and enabling broad application across multiple disease states
Solution Approach 2:
The patent introduces sensor elements as intermediaries that bind to biomolecules in blood plasma, forming biomolecule corona signatures that serve as indirect markers for cancer detection, thereby bypassing the need for direct identification of specific cancer biomarkers
2Reliability
If traditional cancer detection methods are used, then detection is possible, but sensitivity and specificity are insufficient leading to late detection and low survival rates
Solution Approach 1:
The sensor array divides the detection task into multiple parallel measurements using different sensor elements, each detecting specific biomolecule patterns. This segmentation enables comprehensive analysis of the biomolecule corona to achieve high sensitivity and specificity for early cancer detection
Solution Approach 2:
The patent changes the detection parameters by measuring the composition and structure of biomolecule corona signatures rather than relying on traditional single-biomarker assays, enabling detection at earlier stages with higher accuracy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor array provides accurate and sensitive detection of various diseases, including pre-symptomatic stages, by analyzing the biomolecular fingerprint, enhancing early diagnosis and prognosis with a dynamic range of ten orders of magnitude in protein detection.
Implementation Method 1
each sensor element is able to bind a plurality of biomolecules in a sample to produce a biomolecule corona signature
Data Source
AI summary
The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.