Biomolecule Sensor Array for Early Disease State Fingerprinting
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Solution Overview
Problem
Current methods for early detection of cancers lack specificity and sensitivity, particularly for biomarkers that can identify cancers at various stages and provide negative results when the person is cancer-free, necessitating a novel approach for early detection.
Innovation Solution
A sensor array comprising a plurality of nanoscale sensor elements with distinct physicochemical properties that bind to biomolecules in a sample, producing a unique biomolecule corona signature, allowing for the determination of a disease state through a biomolecule fingerprint.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If molecular blood analysis for biomarkers is used for early detection, then detection capability is improved, but specificity and sensitivity remain insufficient for most cancers
Solution Approach 1:
The invention divides the detection system into multiple sensor elements, each with distinct surface properties that selectively bind to different biomolecules. This segmentation allows simultaneous detection of multiple cancer types and stages using a single integrated array, improving both sensitivity and specificity by examining multiple biomarker profiles concurrently rather than relying on single biomarker tests.
Solution Approach 2:
Each sensor element in the array is designed with unique surface properties (charge, hydrophobicity, size) that create locally optimized binding conditions for specific biomolecules. This local quality differentiation enables the array to distinguish between various cancer types and stages based on their characteristic biomolecule profiles, achieving high detection precision without false positives.
2Adaptability or versatility
If multiple biomarkers are introduced to improve detection, then detection range is expanded, but the complexity of the detection system increases
Solution Approach 1:
The invention merges multiple detection functions into a single integrated sensor array where numerous sensor elements work simultaneously to detect diverse biomarkers. This combining approach expands detection range across multiple cancer types while maintaining manageable system complexity through unified hardware and software architecture, avoiding the need for separate detection systems for different biomarkers.
Solution Approach 2:
The sensor array is designed as a universal platform capable of detecting various biomolecules associated with different cancer types and stages using a single integrated system. The array's multi-functionality allows it to examine multiple biomarker profiles concurrently, expanding detection range without requiring multiple specialized systems, thus managing complexity through versatility.
3Measurement precision
If existing sensor arrays are used for disease detection, then detection is possible, but they cannot determine disease state on a continuum of health
Solution Approach 1:
The invention enables dynamic assessment of disease progression by continuously monitoring changes in biomolecule profiles across the continuum of health. The sensor array can detect early subtle changes in biomarker expression that indicate pre-disease states or early-stage cancers, allowing real-time tracking of disease progression rather than static detection, thereby improving measurement precision for disease state determination.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor array effectively differentiates disease states by recognizing a biomolecular fingerprint, enabling early detection of various diseases and disorders, including cancers, cardiovascular diseases, and neurological disorders, with high sensitivity and specificity.
Implementation Method 1
each sensor element is able to bind a plurality of biomolecules in a sample to produce a biomolecule corona signature
Data Source
AI summary
The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.