Biomolecule Wave Characterization for Developability Screening
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Solution Overview
Problem
The properties of biomolecules, particularly in foodstuffs, personal care products, and therapeutic compositions, are difficult to determine accurately, leading to potential late-stage failures in clinical research and challenges in manufacturability and safety profiles.
Innovation Solution
A method and apparatus for biophysical characterization of biomolecules using wave data analysis, involving the generation of physical waves by contacting a droplet of the biomolecule with a liquid, measuring these waves, and applying dimensionality reduction techniques and machine learning to determine biophysical characteristics such as sensory properties and developability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional methods are used to determine biomolecule properties, then the evaluation process is simple, but the measurement precision is insufficient leading to inaccurate determination of biophysical properties
Solution Approach 1:
The patent segments the complex characterization task into multiple independent measurement modules, each targeting specific biophysical properties (surface tension, viscosity, elasticity, etc.). Each module uses specialized sensors optimized for its specific parameter, allowing high-precision measurements without requiring a single overly complex integrated system.
Solution Approach 2:
The patent creates a universal characterization platform that can measure multiple biophysical properties using a single integrated apparatus. The system incorporates multiple sensor types and measurement capabilities within one device, enabling comprehensive biophysical profiling of biomolecules without requiring separate specialized equipment for each parameter.
2Reliability
If comprehensive biophysical characterization is performed, then the reliability of biomolecule evaluation improves, but the time required for measurement increases
Solution Approach 1:
The patent performs rapid preliminary screening measurements to quickly filter and identify promising biomolecule candidates. These initial measurements assess key biophysical properties to determine suitability for further study, enabling early elimination of unsuitable candidates and reducing the time spent on comprehensive characterization of all samples.
Solution Approach 2:
The patent implements continuous measurement capabilities where multiple biophysical parameters can be measured simultaneously or in rapid succession without interruption. The system maintains continuous monitoring and data collection, eliminating idle time between measurements and providing comprehensive characterization efficiently through parallel processing of multiple properties.
3Reliability
If detailed developability assessment is conducted, then the safety profile and manufacturability evaluation improve, but the difficulty of detecting and measuring increases
Solution Approach 1:
The patent introduces intermediary measurement parameters that indirectly reflect complex developability characteristics. Instead of directly measuring difficult-to-obtain safety and manufacturability parameters, the system measures related biophysical properties (such as molecular size, surface properties, stability) that serve as proxies or indicators for these harder-to-measure developability attributes.
Solution Approach 2:
The patent replaces complex mechanical and laboratory-based assessment methods with optical, electrical, and computational measurement techniques. The system uses sensors and imaging technologies to capture biophysical data that can be processed algorithmically to predict developability characteristics, substituting traditional mechanical testing with non-contact, easier-to-implement measurement approaches.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate assessment of biomolecules' biophysical properties, improving manufacturability and safety profiles, and facilitating the identification of suitable candidates through comparisons with target biomolecules.
Implementation Method 1
Lucassen waves are characterised by a displacement from equilibrium of a notional fluid particle at a surface of a wave-medium by oscillation in a direction parallel to that surface at equilibrium and parallel to the direction of propagation of the wave
Implementation Method 2
As a result of these perturbation, different types surface waves may be generated on a surface e.g. a surface of a fluid (e.g. a liquid) forming an interface with another fluid (e.g. air)
Implementation Method 3
measuring these waves
Data Source
AI summary
An aspect of the disclosure provides a method of biophysical characterisation of a biomolecule of a certain biomolecule class, or a composition thereof, said method comprising the steps of: i) obtaining wave data for a sample based on physical measurements of a wave generated, in a liquid system, by providing contact between a droplet of the sample and the liquid system, wherein the wave comprises modes encoding characteristics of the interaction between the sample and the liquid system, wherein the sample contains the biomolecule, or a composition thereof, for analysis; ii) providing a biophysical characterisation of the biomolecule or the composition comprising the biomolecule based on the wave data.