Bionic Digestive System Simulating Gastric Peristalsis
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Solution Overview
Problem
Existing in vitro simulated human gastrointestinal digestion devices fail to accurately simulate the real gastrointestinal peristalsis and often result in inaccurate measurement due to the accumulation of intermediates and products, which inhibit digestive enzymes, and lack the structural and functional similarity to the human stomach and intestines.
Innovation Solution
A visual bionic digestive system for a human gastrointestinal tract model is developed, comprising a reaction system with bionic stomach, small intestine, and large intestine systems, and a control system with a PLC, peristaltic pumps, and solenoid valves, which simulates real gastric peristalsis through a circulating water system, allowing independent control of each reactor and real-time observation of sample changes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If stirring is used to simulate gastrointestinal peristalsis, then mixing of digestive juices and food is achieved, but the motion differs greatly from actual peristalsis and cannot well simulate the real gastrointestinal tract
Solution Approach 1:
The patent uses a bionic stomach model that copies the actual anatomical structure of the human stomach, including the gastric body, antrum, and pylorus. This structural copying allows the model to naturally exhibit peristaltic motion patterns similar to real gastrointestinal tract, resolving the contradiction between simulation accuracy and operational simplicity.
Solution Approach 2:
The patent replaces traditional mechanical stirring devices with a physiological model that uses peristalsis simulation through controlled compression and relaxation of the bionic stomach chambers. This substitution achieves more realistic motion patterns without complex mechanical stirring mechanisms.
2Device complexity
If a single reactor is used to simulate the gastrointestinal tract, then device simplicity is maintained, but intermediates and products accumulate in the reactor to inhibit digestive enzymes
Solution Approach 1:
The patent divides the gastrointestinal simulation into multiple sequential chambers: gastric body chamber, gastric antrum chamber, and pylorus chamber. This segmentation allows progressive digestion and prevents accumulation of inhibitory products in a single reactor, while maintaining a relatively simple overall device structure.
Solution Approach 2:
The patent implements dynamic flow between chambers by controlling the opening and closing of pyloric sphincter mechanisms. This dynamic operation allows intermediates to progress through chambers in a physiological manner, preventing static accumulation and enzyme inhibition.
3Device complexity
If traditional triangular flask or beaker is used as simulated gastric digestion device, then device simplicity is achieved, but digestive products have inhibitory effect on digestion reaction resulting in inaccurate measurement
Solution Approach 1:
The patent segments the digestion process into distinct chambers (gastric body, antrum, pylorus) that can be independently controlled and monitored. This segmentation prevents product inhibition by maintaining separate reaction zones and allows more accurate measurement of digestion at each stage.
Solution Approach 2:
The patent introduces a pyloric sphincter mechanism as an intermediary between chambers, controlling the flow of digested material. This intermediary allows precise control over reaction progression and enables accurate measurement of digestion products at each stage without interference from later-stage inhibitory products.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides a more accurate simulation of the digestive process by mimicking real gastric and intestinal peristalsis, allowing for independent operation of each reactor, reducing enzyme inhibition, and enabling real-time data collection for optimizing model parameters, thus improving the accuracy of digestion simulations.
Implementation Method 1
The water interlayer of each reaction tank is communicated with a thermostatic water bath to achieve a 37° C. constant temperature effect. The peristalsis of each reaction tank is simulated by magnetic stirring.
Implementation Method 2
The water interlayer of each reaction tank is communicated with a thermostatic water bath to achieve a 37° C. constant temperature effect.
Implementation Method 3
The peristalsis of each reaction tank is simulated by magnetic stirring.
Implementation Method 4
the fermentation system comprises a culture medium bottle with a stirring device and a bioreactor
Data Source
AI summary
The present invention discloses a visual bionic digestive system for a human gastrointestinal tract model, and belongs to the field of bionic digestive systems. The visual bionic digestive system for a human gastrointestinal tract model comprises a reaction system and a control system; the reaction system comprises a bionic stomach system, a bionic small intestine system, a bionic large intestine system and a filtering system; the control system comprises a PLC, peristaltic pumps, and a circulating water tank; the water inlet pipes of the bionic stomach system, the bionic small intestine system, and the bionic large intestine system are connected to a water outlet of the circulating water tank through water pipes; the water outlet pipes of the bionic stomach system, the bionic small intestine system, and the bionic large intestine system are connected to a water inlet of the circulating water tank through water pipes, solenoid valves are arranged on the water pipes, and the solenoid valves on the water pipes are controlled by the PLC. The bionic digestive system provided by the present invention has the advantages of strong visibility, high automation, device modularization, and simple and effective gastrointestinal peristalsis simulation way.