Bionic Dressing Composition for Rapid Hemostasis and Bilayer Crosslinking
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Solution Overview
Problem
Current hydrogel dressings lack rapid hemostatic properties, fail to maintain a moist and sterile environment, and often cause scar formation, posing challenges in managing extensive wounds with uncontrollable bleeding and vascular damage.
Innovation Solution
A bionic dressing-forming composition comprising an aqueous and oil phase with photopolymerizable functional groups that spontaneously form a double-layer structure upon application, providing rapid hemostasis, wound adhesion, and a sterile environment through a hydrophobic and hydrophilic polymer layer, enhanced with antimicrobial agents like triclosan and hemostatic agents like calcium ions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current hydrogel dressings are used, then wound adhesion and mechanical properties are limited, but they can maintain a moist repair microenvironment and absorb tissue exudate
Solution Approach 1:
The patent uses a composite material system consisting of hydrophobic polymer and hydrophilic hydrogel phases. The hydrophobic phase provides mechanical strength and adhesion, while the hydrophilic phase maintains moisture and absorbs exudate, resolving the contradiction between mechanical properties and moisture maintenance capability
Solution Approach 2:
The dressing structure is divided into two phases with different local properties: the hydrophobic phase located in the continuous matrix provides structural support, while the hydrophilic phase forms dispersed gel regions that maintain moisture. This local differentiation allows simultaneous achievement of strong adhesion and effective moisture management
2Reliability
If current hydrogel dressings are used, then they can stimulate extracellular matrix, but they lack rapid hemostatic properties and cannot be applied to extensive emergency wounds with uncontrollable bleeding
Solution Approach 1:
The patent modifies the physical and chemical parameters of the dressing by incorporating photopolymerizable functional groups that enable rapid crosslinking upon light exposure. This parameter change transforms the dressing from a slow-setting hydrogel to a rapidly固化 material that can achieve hemostasis and adhere to extensive wounds within minutes, while maintaining versatility for different wound types
3Reliability
If current hydrogel dressings are used, then they can be applied to wounds, but they exhibit excessive water evaporation and inevitable microbial infections
Solution Approach 1:
The dual-phase composite structure creates a synergistic effect where the hydrophobic polymer phase forms a barrier layer that reduces water evaporation, while the hydrophilic hydrogel phase maintains appropriate moisture levels for wound healing. This composite architecture simultaneously provides microbial protection and prevents excessive evaporation
Solution Approach 2:
The hydrophobic polymer phase forms a flexible barrier film over the wound surface that acts as a physical shield against microbial infection while allowing controlled moisture transfer. This thin film structure prevents excessive evaporation without compromising wound bed moisture
4Reliability
If current hydrogel dressings are used, then they can maintain wound moisture, but they cause obvious scar formation affecting patient appearance and quality of life
Solution Approach 1:
The patent changes the chemical composition parameters by incorporating specific hydrophilic polymers and active ingredients that promote organized collagen deposition and reduce inflammatory responses. This parameter modification allows the dressing to maintain moisture while actively preventing scar formation through biochemical modulation of the wound healing process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bionic dressing achieves rapid hemostasis, adheres firmly to wounds, maintains a moist and sterile environment, and promotes scarless healing by inhibiting scar formation and reducing infection risk, suitable for irregular or large-area wounds.
Implementation Method 1
the first photopolymerizable functional group and the second photopolymerizable functional group comprises a —C═C— bond and are capable of polymerization and/or crosslinking initiated by light
Implementation Method 2
upon application of the composition, the oil phase and the aqueous phase spontaneously form a bilayer thereby forming a bionic dressing with a double-layer cross-linked structure
Data Source
AI summary
A bionic dressing-forming composition, a bionic dressing, and a method of forming the bionic dressing. The bionic dressing-forming composition herein includes an aqueous phase and an oil phase, wherein the oil phase includes a hydrophobic prepolymer or a hydrophobic monomer, the hydrophobic prepolymer or the hydrophobic monomer has a first photopolymerizable functional group, and the oil phase has an intrinsic viscosity lower than 106 mPa·s at ambient temperature; and the aqueous phase includes a hydrophilic hydrogel prepolymer or a hydrophilic hydrogel monomer and an active ingredient, and the hydrophilic hydrogel prepolymer or the hydrophilic hydrogel monomer has a second photopolymerizable functional group, the aqueous phase has an intrinsic viscosity lower than 106 mPa·s at ambient temperature. The first photopolymerizable functional group and the second photopolymerizable functional group includes a —C≡C— bond and are capable of polymerization and/or crosslinking initiated by light. Upon application of the composition, the oil phase and the aqueous phase are capable of forming a bilayer and forming a bionic dressing with a double-layer crosslinked structure of hydrophobic polymer and hydrophilic hydrogel.