Biological Particle Detection via Integrated Optical Splitting

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Solution Overview

Problem

Conventional scanning and detecting devices for biological particles are bulky, heavy, and suffer from mechanical interference due to poor integration of moving parts, leading to inefficient detection and positioning of biological particles.

Innovation Solution

A detecting device comprising a detecting carrier and an optical system that includes an excitation light source, a filter and spectroscope group, a photomultiplier tube, and a charge-coupled device, which separates emission light into two detecting lights to efficiently position and identify biological particles with precise movement.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a combination of mirror group, scanning sensor, and light source is added near the device carrier to obtain better image resolution, then the detection precision is improved, but the device volume and weight increase significantly

Engineering Contradiction:
Improveimage resolutionVSAvoiddevice volume
Core Design Contradiction:
Measurement precisionVSVolume of moving object

Solution Approach 1:

The patent combines the scanning sensor and mirror group into a single integrated scanning detection assembly that moves together as one unit, eliminating the need for separate moving components. This merging reduces the overall device volume and weight while maintaining the detection precision through the coordinated operation of the integrated components.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The scanning detection assembly is designed to perform multiple functions simultaneously - scanning, detecting, and imaging - using a single integrated structure. This multi-functionality eliminates the need for separate dedicated components for each function, thereby reducing device volume and weight while achieving the required image resolution.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Measurement precision

If a combination of mirror group, scanning sensor, and light source is added near the device carrier to obtain better image resolution, then the detection precision is improved, but the device weight increases significantly

Engineering Contradiction:
Improveimage resolutionVSAvoiddevice weight
Core Design Contradiction:
Measurement precisionVSWeight of moving object

Solution Approach 1:

The patent combines the scanning sensor and mirror group into a single integrated scanning detection assembly that moves together as one unit, eliminating the need for separate moving components. This merging reduces the overall device volume and weight while maintaining the detection precision through the coordinated operation of the integrated components.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The scanning detection assembly is designed to perform multiple functions simultaneously - scanning, detecting, and imaging - using a single integrated structure. This multi-functionality eliminates the need for separate dedicated components for each function, thereby reducing device volume and weight while achieving the required image resolution.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Productivity

If separate scanning sensors are used in the combination scanning and detecting device, then the detection capability is enhanced, but mechanical interference occurs due to poor integration of moving devices

Engineering Contradiction:
Improvedetection capabilityVSAvoidmechanical interference
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent combines the scanning sensor and mirror group into a single integrated scanning detection assembly that moves together as one unit, eliminating the need for separate moving components. This merging reduces the overall device volume and weight while maintaining the detection precision through the coordinated operation of the integrated components.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device achieves high-efficiency detection and high accuracy in locating biological particles by integrating the photomultiplier tube and charge-coupled device, reducing the overall volume and weight, and minimizing mechanical interference.

Implementation Method 1

The light source emits a high-penetration light (e.g. near-infrared light, laser light) and illuminates a plurality of biological particles on a device carrier, so that at least part of the biological particles emit an emission light after being illuminated

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Implementation Method 2

The filter and spectroscope group includes a beam splitter located on a light path of the emission light and is adapted to separate the incident emission light into a first detecting light and a second detecting light that account for different proportions of the emission light

Methodology Applied
Scientific EffectLight splitting: Reflection

Data Source

PatentUS12287276B2Detecting device for detecting biological particles and detecting method thereof
Publication Date: 2025.04.29 LIQBIO BIOMEDICAL CO LTD
  • US12287276B2 patent drawing
  • US12287276B2 patent drawing
  • US12287276B2 patent drawing

AI summary

A detecting device for detecting biological particles includes an optical system including an excitation light source, a filter and spectroscope group, a photomultiplier tube, and a charge-coupled device. The excitation light source illuminates the biological particles on a detecting carrier of the detecting device. A kind of target biological particles in the biological particles is excited to generate an emission light. The emission light enters the filter and spectroscope group to be separated into a first detecting light and a second detecting light. After the photomultiplier tube receives the first detecting light, the photomultiplier tube transmits a regional positioning signal to a processor of the detecting device. After the charge-coupled device receives the second detecting light, the charge-coupled device transmits an image signal to the processor. The processor obtains a precise location of the target biological particles based on the regional positioning signal and the image signal. A detecting method of the detecting device is also provided.