Bioparticle Positioning Sensing System Using Dual-Sensor Segmentation
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Solution Overview
Problem
Conventional bioparticle detection methods struggle with accurately detecting samples with large quantities or weak fluorescence, leading to low detection efficiency and high error rates.
Innovation Solution
A bioparticle positioning sensing system that uses a first sensor to quickly screen and select detection areas with specific bioparticles, recording location information, and a second sensor to perform high-precision detection within those areas, recording accurate locations and related information.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional sensors are used to detect bioparticles, then the detection can be performed, but the detection limit is higher and cannot accurately detect samples with weak fluorescence
Solution Approach 1:
The detection process is divided into two stages: a screening stage using a first sensor to identify potential detection areas, and a precise detection stage using a second sensor to accurately detect bioparticles in selected areas. This segmentation allows the system to achieve both high precision and reliability by filtering out false positives in the first stage and then performing targeted high-precision detection in the second stage.
Solution Approach 2:
The first sensor acts as an intermediary that performs preliminary detection and selection before the second sensor performs the actual precise detection. This intermediary component filters the detection process, ensuring that only areas with potential bioparticles are subjected to high-precision detection, thereby improving overall detection accuracy and reliability.
2Productivity
If conventional sensors capture images through entire visual fields, then complete images can be formed, but the sensing time is long and detection efficiency is low
Solution Approach 1:
Instead of capturing complete images through entire visual fields, the system segments the detection area into multiple regions and uses the first sensor to quickly screen and identify specific areas of interest. This segmentation approach significantly reduces the sensing time required while maintaining detection efficiency, as the second sensor only needs to detect within the selected areas rather than the entire field.
3Measurement precision
If conventional assays use charge-coupled devices or photosensitive devices, then imaging can be performed, but the detection limit is higher causing higher percentage of detection errors
Solution Approach 1:
The first sensor serves as an intermediary that performs preliminary screening and selection of detection areas. By filtering out areas without bioparticles in this first stage, the system reduces the proportion of false positive detections that would occur if the second sensor attempted to detect across the entire field, thereby reducing the detection error rate while maintaining high precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves high detection efficiency and precision, effectively addressing the limitations of conventional methods when dealing with large or weakly fluorescent samples.
Implementation Method 1
providing an excitation energy to the carrier by an excitation device, which makes the at least one tag on the first bioparticle emit a radioactive energy
Implementation Method 2
after the first sensor receives the radioactive energy, the first sensor defines one of the detection areas where the radioactive energy comes from as an activity detection area
Data Source
AI summary
A sensing method of bioparticle positioning includes the steps of: providing a carrier divided into multiple detection areas; adding bioparticle sample in the carrier, wherein the bioparticle sample includes first bioparticle with biomarker and interacts with corresponding tag; providing excitation energy that makes the tag on the first bioparticle emit radioactive energy; moving the first sensor to the detection area respectively; after receiving radioactive energy, defining the detection area where the radioactive energy comes from as activity detection area, and sending location information of the activity detection area to processing module; according to location information, moving second sensor to detection area, detecting the accurate location of the first bioparticle in activity detection area, and sending the accurate location to processing module. A bioparticle positioning sensing system is also provided herein. The method and system above detect specific bioparticle quickly and improve the detection efficiency.