Biopolymer Core-Shell Carrier for Transdermal Delivery
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Solution Overview
Problem
Current cosmetic and pharmaceutical formulations using synthetic surfactants and polymers for enhancing skin penetration of active substances pose safety concerns due to toxicity and allergenicity, necessitating a biocompatible alternative for effective transdermal absorption.
Innovation Solution
A core-shell network structure comprising a prolamin core, surrounded by pullulan and pectin, forming a biopolymer-based carrier that facilitates the transdermal absorption of active substances by creating a stable network for enhanced delivery through the stratum corneum.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If synthetic surfactants and polymers are used to enhance skin penetration of active substances, then the transdermal absorption is improved, but safety issues such as toxicity and allergenicity arise
Solution Approach 1:
The patent changes the material composition parameter from synthetic polymers to biopolymers (chitosan, gelatin, alginate, pectin, starch) while maintaining the nanoparticle carrier function. This parameter change resolves the contradiction by providing biocompatible materials that achieve transdermal absorption without the toxicity and allergenicity associated with synthetic surfactants and polymers.
Solution Approach 2:
The patent employs composite nanoparticle structures combining multiple biopolymers (e.g., chitosan-gelatin core-shell nanoparticles, or alginate-pectin complexes) to achieve enhanced transdermal absorption. The composite structure leverages the synergistic properties of different biopolymers to improve penetration efficiency while maintaining biocompatibility, thus resolving the contradiction between effectiveness and safety.
2Object-affected harmful factors
If biopolymers are used to create a biocompatible carrier, then safety is improved, but the transdermal absorption capability may be reduced compared to synthetic carriers
Solution Approach 1:
The patent utilizes core-shell nanoparticle structures where one biopolymer forms the core and another forms the shell (e.g., chitosan core with gelatin shell). This nested structure allows the core to provide structural integrity and loading capacity while the shell enhances biocompatibility and facilitates skin penetration through specific interactions with skin proteins, thereby achieving both safety and effectiveness.
Solution Approach 2:
The patent introduces amphiphilic biopolymer segments or surface-modified biopolymers that act as intermediaries between the hydrophobic active substances and the hydrophilic skin barrier. These intermediary structures enable effective drug loading and simultaneous penetration through the stratum corneum, resolving the contradiction between biocompatibility and absorption capability.
Data Source
AI summary
The present disclosure relates to an active substance carrier comprising a core-shell network structure formed using a biopolymer. In an aspect of the present disclosure, the core-shell network structure comprises a core-shell particle comprising: a core comprising prolamin; and a shell comprising pullulan and pectin, wherein the pullulan comprised in the shell surrounds the core and the pectin is located in the outermost layer of the shell, so that a network is formed between the core-shell particles. It can effectively facilitate the transdermal absorption of an active substance.