3D Bioprinted Tissue Model with Parallel Vessel Walls
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Solution Overview
Problem
Existing bioprinting methods fail to create tissue models with channels that match the cross-section of native vessels in living organisms, and the printing of vessel walls according to a pattern parallel to the channel axis is not effectively addressed, leading to risks of coagulation inside bionic organs.
Innovation Solution
A method for manufacturing a perfusable three-dimensional tissue model using 3D bioprinting, where the vascular system is bioprinted using extrusive methods with bioink, and the walls of the channel are printed parallel to the channel axis, using bioinks with specific compositions and properties to ensure structural integrity and cell viability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If the vascular system is bioprinted with walls opening and closing the channel printed perpendicular to the channel axis, then the manufacturing process is simpler, but the risk of coagulation inside the bionic organ increases
Solution Approach 1:
The patent applies different printing orientations to different regions of the vascular system. The channel walls are printed parallel to the channel axis in critical regions where coagulation risk is highest, while other regions may use different orientations. This localized optimization resolves the contradiction by applying the most reliable printing method where needed without compromising overall manufacturing simplicity.
2Ease of manufacture
If the channel cross-section does not match the cross-section of native vessels, then the manufacturing process is easier, but the perfusion function and safety of bionic organs are compromised
Solution Approach 1:
The patent employs parameter changes in the bioink formulation and printing process to achieve precise control over channel cross-sectional geometry. By adjusting bioink viscosity, printing pressure, nozzle diameter, and layer thickness parameters, the channel cross-section is optimized to match native vessel geometry, thereby ensuring proper perfusion function while maintaining manufacturability through controlled parameter adjustment.
3Reliability
If the walls closing the channel are printed parallel to the channel axis, then the risk of coagulation is reduced, but the manufacturing complexity increases
Solution Approach 1:
The patent segments the vascular system printing into distinct functional components: channel formation, wall construction, and lumen definition. By dividing the complex task of printing parallel walls into separate printing steps and using multi-nozzle systems, the manufacturing complexity is managed through systematic segmentation rather than monolithic processing.
Solution Approach 2:
The patent uses supporting bioink materials and temporary structures as intermediaries during the printing process. These intermediaries enable the formation of parallel walls and proper channel geometry during printing, then are removed or integrated afterward. This intermediary approach simplifies the actual wall printing process while achieving the desired parallel orientation to prevent coagulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enables the creation of tissue models with channels that mimic the cross-section of native vessels, reducing the risk of coagulation and ensuring the perfusion of fluids, thereby enhancing the functionality and safety of bionic organs.
Implementation Method 1
placing the resulting system in an incubator, in a temperature in which bioink for printing the vascular system undergoes melt
Data Source
AI summary
A method For manuFacturing a perFusable three-dimensional tissue model, containing therein a channel distributed across its entire structure, enabling the Flow oF Fluids, wherein bioprinting a vascular system with the extrusive method using bioink, the walls opening and closing the channel in its upper part being printed parallel to the channel axis, and bioprinting oF the model body with the extrusive method using bioink, the bioink For printing the body being diFFerent From the bioink used For bioprinting the vessels, placing the resulting system in an incubator, in a temperature in which bioink For printing the vascular system undergoes melt, removing the bioink, optionally, causing growth in the channel by means oF cells in a medium, wherein, the cross-section oF the channel being the same as the cross-section oF native vessels present in a living organism. The inventions relates to a bionic model with a perFusable system.